Adrenoceptor and cholinoceptor mediated responses of the isolated human urethra.
Adrenoceptor and cholinoceptor mediated responses of the isolated human urethra.
复制标题
肾上腺素受体和胆碱受体介导离体人尿道的反应。
DOI：
--
复制
发表时间：
1977
影响因子：
--
通讯作者：
C. Persson
中科院分区：
文献类型：
--
作者：
A. Ek;P. Alm;K. Andersson;C. Persson
对因膀胱恶性肿瘤而行全膀胱尿道切除术的男性和女性患者，分别从孤立尿道和尿道膀胱交界处的不同部位获得平滑肌准备。该制剂悬浮在含碳气泡的克雷布斯溶液（37°C）中。记录等长张力。42种药物反应性制剂中有29种表现出自发收缩活性。河豚毒素、阿托品和苯氧苄胺对其没有影响，这表明它是肌源性的。去甲肾上腺素以浓度相关的方式收缩来自尿道各部分的制剂，包括尿道膀胱交界处。男女尿道不同部位对去甲肾上腺素的敏感性无差异。苯氧苄胺可抑制去甲肾上腺素的诱导作用，提示其可能是通过α-肾上腺素受体介导的。肾上腺素、苯肾上腺素、麻黄碱和去甲麻黄碱具有收缩作用，可以通过……
Smooth muscle preparations from various parts of the isolated urethra and the urethrovesical junction were obtained from male and female patients undergoing total cysto-urethrectomy because of bladder malignancy. The preparations were suspended in Krebs solution (37°C) bubbled with carbogen. Isometric tension was recorded. Twenty-nine out of 42 drug-responsive preparations exhibited a spontaneous contractile activity. This was unaffected by tetrodotoxin, atropine, and phenoxybenzamine, suggesting it was of myogenic origin. Noradrenalin contracted preparations from all parts of the urethra, including the urethrovesical junction, in a concentration-related way. No differences in the sensitivity to noradrenalin between different parts of the male or female urethra could be established. The noradrenalin-induced effects were inhibited by phenoxybenzamine, suggesting that they were mediated via α-adrenoceptors. Adrenalin, phenylephrine, ephedrine, and norephedrine had contracting effects that could be blocked b...