Association of 82 Rubidium and 11C-methionine uptake in brain tumors measured by positron emission tomography
Association of 82 Rubidium and 11C-methionine uptake in brain tumors measured by positron emission tomography
复制标题
通过正电子发射断层扫描测量脑肿瘤中 82 铷和 11C-蛋氨酸摄取的关联
DOI：
10.1007/bf00177480
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发表时间：
1996
影响因子：
3.9
通讯作者：
K. Leenders
中科院分区：
文献类型：
--
作者：
U. Roelcke;E. Radü;S. Ametamey;R. Pellikka;W. Steinbrich;K. Leenders
摘要正电子发射断层扫描 (PET) 研究表明，主动转运的改变有助于增加人脑肿瘤中氨基酸的净积累。我们使用 PET 比较了 30 名患有各种脑肿瘤的患者对 11C-蛋氨酸 (MET) 和 K+ 类似物 82 铷 (RUB) 的摄取情况。 MET 和 RUB 在肿瘤组织中迅速积累，此后平均保持在稳定水平，从中计算标准化摄取值（组织放射性除以注射放射性 × 体重 (NU)）。还使用非线性速率常数拟合对 17/30 例患者的 K1 (RUB) 和 K1, k2, 0 (MET) 进行了估计。 NU 和 K1 值与 MET（斯皮尔曼等级 p < 0.005）和 RUB（p < 0.001）显着相关。与神经胶质瘤相比，脑膜瘤中 MET 和 RUB 的 NU 和 K1 值较高，并且与整个肿瘤谱显着相关 (p < 0.001)。当排除脑膜瘤时，相关性得以维持。肿瘤中 MET（代谢率）的 K3 值在正常大脑的范围内。对于正常大脑，RUB 和 MET 之间没有相关性。随着RUB摄入量的增加，NU MET与NU RUB的比率接近1.0。这些结果表明，除了主动转运之外，穿过血脑屏障（BBB）的被动扩散也可能是 MET 从血液摄取到肿瘤组织中的原因。这可能限制了 MET 在存在 BBB 破坏的脑部病变的鉴别诊断中的使用。
SummaryPositron emission tomography (PET) studies have indicated that alteration of active transport contributes to increased net amino acid accumulation into human brain tumors. We compared the uptake of 11C-methionine (MET) and the K+ analog 82Rubidium (RUB) in 30 patients suffering from various brain tumors using PET. MET and RUB accumulated rapidly in tumor tissue and remained on average at a stable level thereafter from which normalized uptake values were calculated (tissue radioactivity over injected radioactivity × body weight (NU)). K1 (RUB) and K1, k2, 0 (MET) were also estimated using non-linear rate constant fitting in 17/30 patients. NU and K1 values were significantly correlated for MET (Spearman Rank p < 0.005) and RUB (p < 0.001). NU and K1 values for MET and RUB were higher in meningiomas compared to gliomas and were significantly correlated for the whole spectrum of tumors (p < 0.001). When meningiomas were excluded, the correlation was maintained. K3 values for MET (metabolic rate) in tumors were in the range of normal brain. No correlation between RUB and MET was found for normal brain. With increasing RUB uptake, the ratio of NU MET over NU RUB approached the value of 1.0. These results suggest that apart from active transport, also passive diffusion across the blood-brain barrier (BBB) may account for MET uptake from blood into tumor tissue. This probably limits the use of MET in the differential diagnosis of brain lesions where BBB disruption is present.