Remission of remitting seronegative symmetrical synovitis with pitting edema after unrelated cord blood transplantation for myelodysplastic syndrome.
Remission of remitting seronegative symmetrical synovitis with pitting edema after unrelated cord blood transplantation for myelodysplastic syndrome.
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骨髓增生异常综合征的无关脐带血移植后缓解性血清阴性对称性滑膜炎伴凹陷性水肿的缓解。
DOI：
10.1007/s00277-015-2555-0
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Takahashi S.
中科院分区：
文献类型：
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作者：
Ishii H;Konuma T;Ohnuma K;Hosono O;Tanaka H;Kato S;Tojo A;Takahashi S.
亲爱的编辑， 据报道，同种异体造血干细胞移植 (HSCT) 可诱导同时发生或单独发生的自身免疫性疾病的缓解 [1-3]。我们报告一例骨髓增生异常综合征（MDS）患者，其缓解期血清阴性对称性滑膜炎伴凹陷性水肿（RS3PE）在无关脐带血移植（CBT）后未经任何治疗即可获得缓解。患者为一名 60 岁男性，有两个月的手关节晨僵、多关节痛、手足背水肿病史入院。实验室检查结果显示基质金属蛋白酶 3 (MMP-3) 升高至 824.1 ng/mL (< 121)，并伴有大细胞性贫血。类风湿因子、抗核抗体、抗环瓜氨酸肽抗体均为阴性。手部磁共振成像 (MRI) 显示软组织肿胀，但没有骨质侵蚀。根据这些数据，他被诊断患有 RS3PE。骨髓检查发现红系发育不良和染色体异常，包括 dup (1)(q21; q42)、
Dear Editor, Allogeneic hematopoietic stem cell transplantation (HSCT) has been reported to induce remission of coincidental or sole autoimmune disease [1–3]. We report on a patient with myelodysplastic syndrome (MDS) whose remitting seronegative symmetrical synovitis with pitting edema (RS3PE) achieved remission without any treatment after unrelated cord blood transplantation (CBT).A 60-year-old man with a two-month history of morning stiffness in the hand joints, polyarthralgia, and edema of the dorsum of both the hands and feet was admitted to our hospital. Laboratory findings revealed an elevated matrix metalloproteinaise-3 (MMP-3) of 824.1 ng/mL (< 121), along with macrocytic anemia. Rheumatoid factor, antinuclear antibody, and anti-cyclic citrullinated peptide antibody were negative. Magnetic resonance imaging (MRI) of the hands demonstrated soft tissue swelling without bone erosion. Based on these data, he was diagnosed with RS3PE. Bone marrow examination revealed dysplasia of the erythroid series and chromosomal abnormality including dup (1)(q21; q42),