De Gustibus: time scale of loss and recovery of tastes caused by radiotherapy
De Gustibus: time scale of loss and recovery of tastes caused by radiotherapy
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DOI：
10.1016/s0167-8140(02)00025-7
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发表时间：
2002-05-01
影响因子：
5.7
通讯作者：
Van den Bogaert, W
中科院分区：
文献类型：
--
作者：
Maes, A;Huygh, I;Van den Bogaert, W
目的：量化的患病率和痛苦的味觉丧失放疗（RT）后，在不同的时间间隔为头颈cancer.Materials和方法：在四个不同的组的头颈癌患者（共73例），味觉丧失和痛苦，由于味觉丧失进行了评价味觉敏锐度测试和味觉问卷。第1组（n = 17）在RT前进行分析。第2组（n = 17）、第3组（n = 17）和第4组（n = 22）分别在治疗后2、6和12-24个月进行分析。这四个groups.Results之间进行了横断面分析：在RT（组1）开始之前，观察到35，18和6%的患者的苦，盐和甜，分别部分味觉丧失。在RT后2个月（第2组），分别在88%、82%、76%和53%的患者中观察到苦味、咸味、甜味和酸味的味觉丧失（部分或全部）。在6个月时（第3组），71%、65%、41%和41%（苦、盐、甜、酸）的部分味觉丧失，1-2年后（第4组），41%、50%、27%和27%（苦、盐、甜、酸）的部分味觉丧失。味觉丧失引起的痛苦是最常见的第2组（82%）。结论：在这项研究中，RT后味觉丧失被认为是最明显的2个月后。苦味和咸味受损最严重。在治疗后的第一年内逐渐恢复。部分味觉丧失在治疗后1-2年仍持续存在，并导致轻微至中度不适。(C)2002爱思唯尔科学爱尔兰有限公司保留所有权利。
Purpose: To quantify the prevalence and distress of taste loss at different intervals after radiotherapy (RT) for head and neck cancer.Materials and methods: In four different groups of head and neck cancer patients (73 patients in total), taste loss and distress due to taste loss were evaluated by taste acuity tests and taste questionnaires. Group 1 (n = 17) was analyzed prior to RT. Groups 2 (n = 17), 3 (n = 17) and 4 (n = 22) were at 2, 6 and 12-24 months after treatment, respectively. A cross-sectional analysis was performed between these four groups.Results: Prior to initiation of RT (group 1), partial taste loss was observed in 35, 18 and 6% of patients for bitter, salt and sweet, respectively. At 2 months after RT (group 2), taste loss (partial or total) was seen in 88, 82, 76 and 53% for bitter, salt, sweet and sour, respectively. At 6 months (group 3), partial taste loss was seen in 71, 65, 41 and 41% (bitter, salt, sweet, sour) and after 1-2 years (group 4) in 41, 50, 27 and 27% (bitter, salt, sweet, sour). Distress caused by taste loss was most frequent in group 2 (82%).Conclusions: In this study, loss of taste after RT was found to be most pronounced after 2 months. Bitter and salt qualities were most impaired. Gradual recovery was seen during the first year after treatment. Partial taste loss still persisted 1-2 years after treatment and was responsible for slight to moderate discomfort. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.