Does the pathogenesis of SARS-CoV-2 virus decrease at high-altitude?
Does the pathogenesis of SARS-CoV-2 virus decrease at high-altitude?
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DOI：
10.1016/j.resp.2020.103443
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发表时间：
2020-06-01
影响因子：
2.3
通讯作者：
Soliz, Jorge
中科院分区：
文献类型：
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作者：
Arias-Reyes, Christian;Zubieta-DeUrioste, Natalia;Soliz, Jorge
在本研究中，我们分析了西藏以及玻利维亚和厄瓜多尔高海拔地区的 COVID-19 流行病学数据，并与低地数据进行比较，以检验高海拔居民（海拔 2,500 米以上）不太容易在急性 SARS-CoV-2 病毒感染中出现严重不良反应的假设。对现有流行病学数据的分析表明，平衡高海拔缺氧环境的生理适应/适应可以防止急性 SARS-CoV-2 病毒感染的严重影响。讨论了潜在的潜在机制，例如：(i) 高海拔环境导致病毒半衰期缩短，以及 (ii) 缺氧介导的血管紧张素转换酶 2 (ACE2) 下调，血管紧张素转换酶 2 是 SARS-CoV-2 病毒在肺上皮细胞中的主要结合靶点。
In the present study we analyze the epidemiological data of COVID-19 of Tibet and high-altitude regions of Bolivia and Ecuador, and compare to lowland data, to test the hypothesis that high-altitude inhabitants (+2,500 m above sea-level) are less susceptible to develop severe adverse effects in acute SARS-CoV-2 virus infection. Analysis of available epidemiological data suggest that physiological acclimatization/adaptation that counterbalance the hypoxic environment in high-altitude may protect from severe impact of acute SARS-CoV-2 virus infection. Potential underlying mechanisms such as: (i) a compromised half-live of the virus caused by the highaltitude environment, and (ii) a hypoxia mediated down regulation of angiotensin-converting enzyme 2 (ACE2), which is the main binding target of SARS-CoV-2 virus in the pulmonary epithelium are discussed.