Effects of 3-octen-2-one on human olfactory receptor responses to vanilla flavor
Effects of 3-octen-2-one on human olfactory receptor responses to vanilla flavor
复制标题
3-辛烯-2-酮对人类嗅觉受体对香草味反应的影响
DOI：
10.1093/bbb/zbac147
复制
发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Shun'ichi Kuroda
中科院分区：
文献类型：
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作者：
Motoki Yasunaga;Eiji Takai;Shoji Hattori;Kenji Tatematsu;Shun'ichi Kuroda
人类日常感知到的气味大多是复杂的气味。据信，整体复杂气味的调节、增强和抑制是由气味分子之间的相互作用引起的。在这项研究中，为了了解人类嗅觉受体反应水平上气味分子之间的相互作用，使用人类嗅觉受体传感器分析了3-辛烯-2-酮（已被证明可以调节香草风味）的作用，该传感器使用所有人类嗅觉受体（388种）作为传感分子。结果，与香草香料相比，在香草香料中与3-辛烯-2-酮相比，1种共同受体（OR 1D 2）的响应强度协同增强，而1种受体（OR 5 K1）对香草香料的响应被完全抑制。这些结果有力地表明，人类嗅觉受体对复杂气味的反应被相对较少的其他气味分子增强或抑制。
Most of the odors that humans perceive daily are complex odors. It is believed that the modulation, enhancement, and suppression of overall complex odors are caused by interactions between odor molecules. In this study, to understand the interaction between odor molecules at the level of human olfactory receptor responses, the effects of 3-octen-2-one, which has been shown to modulate vanilla flavors, were analyzed using a human olfactory receptor sensor that uses all human olfactory receptors (388 types) as sensing molecules. As a result, the response intensity of 1 common receptor (OR1D2) was synergistically enhanced in vanilla flavor with 3-octen-2-one compared with vanilla flavor, and the response of 1 receptor (OR5K1) to vanilla flavor was completely suppressed. These results strongly suggested that the response of human olfactory receptors to complex odors is enhanced or suppressed by relatively few other odor molecules.