[The replacement processes of growth plate cartilage to bone in endochondral ossification of mandibular condyle].
[The replacement processes of growth plate cartilage to bone in endochondral ossification of mandibular condyle].
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下颌骨髁突软骨内骨化过程中生长板软骨向骨的替代过程[J].
DOI：
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发表时间：
1996
期刊：
影响因子：
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通讯作者：
H. Nagamine
中科院分区：
文献类型：
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作者：
T. Sasaki;T. W. Kim;K. Debari;H. Nagamine
用3周龄雄性比格犬，用光镜和电镜观察下颌髁突软骨-骨替代过程。软骨基质的钙化发生在纵隔的中央区域，而不是在横隔。血管周围单核细胞吸收横隔，开始开放的软骨细胞陷窝。这些细胞吞噬中隔软骨碎片。此后不久，薄骨层被侵入的成骨细胞沉积在剩余的纵隔上。陷窝中的破骨细胞在软骨基质中既没有形成皱褶的边界，也没有形成清晰的区域，但一旦骨层沉积在剩余的软骨中，这些结构就形成了。结果提示，髁突软骨-骨替代包括三个连续过程：1）单核细胞对横隔软骨碎片的降解和吞噬; 2）骨沉积于剩余纵隔; 3）破骨细胞对钙化软骨和骨的降解。
Using 3-week-old male beagle dogs, we examined the cartilage-bone replacement processes in the mandibular condyle by means of light and electron microscopy. Calcification of the cartilage matrix occurred in the central area of the longitudinal septa, but not in the transverse septa. Perivascular mononuclear cells absorbed the transverse septa which initiated the opening of the chondrocytic lacunae. These cells phagocytosed septal cartilage fragments. Shortly thereafter, a thin bone layer was deposited on the remaining longitudinal septa by invading osteoblasts. Osteoclasts in lacunae developed neither ruffled borders nor clear zones in the cartilage matrix, but once the bone layer has been deposited in the remaining cartilage, these structures formed. Our results suggest that the cartilage-bone replacement in mandibular condyle involves three sequential processes: 1) degradation and phagocytosis of cartilage fragments in the transverse septa by mononuclear cells, 2) bone deposition over the remaining longitudinal septa, and 3) degradation of both calcified cartilage and bone by osteoclasts.