CT to cone-beam CT deformable registration with simultaneous intensity correction.
CT to cone-beam CT deformable registration with simultaneous intensity correction.
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CT 到锥束 CT 变形配准，同时进行强度校正
DOI：
10.1088/0031-9155/57/21/6807
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发表时间：
2012-11-07
影响因子：
3.5
通讯作者：
Jiang SB
中科院分区：
文献类型：
--
作者：
Zhen X;Gu X;Yan H;Zhou L;Jia X;Jiang SB
计算机断层扫描（CT）到锥形束计算机断层扫描（CBCT）的可变形图像配准是自适应放射治疗的关键步骤。当前基于强度的配准算法（如demons）可能会在CT-CBCT成像的背景下失败，因为两种模式之间的强度不一致。在本文中，我们提出了一个变种的恶魔，称为变形与强度同时校正（DISC），以处理CT-CBCT图像。DISC通过在恶魔配准的每个迭代步骤对CBCT图像执行自适应强度校正步骤来将其自身与原始恶魔算法区分开来。具体地，CBCT中的体素的强度校正是通过将体素周围的块内的体素强度的一阶矩和二阶矩与CT图像上的体素强度的一阶矩和二阶矩进行匹配来实现的。预计这种策略可以消除CBCT图像中的伪影，并确保两种模式之间的强度一致性。DISC在计算统一设备架构（CUDA）编程环境中的计算机图形处理单元（GPU）上实现。DISC的性能进行了评估模拟患者的情况下，六个临床头颈部癌症患者的数据。实验结果表明，DISC算法对CBCT伪影和灰度不一致具有较强的鲁棒性，与原始DISC算法相比，DISC算法的配准精度有了显著提高。
Computed tomography (CT) to cone-beam computed tomography (CBCT) deformable image registration (DIR) is a crucial step in adaptive radiation therapy. Current intensity-based registration algorithms, such as demons, may fail in the context of CT-CBCT DIR because of inconsistent intensities between the two modalities. In this paper, we propose a variant of demons, called Deformation with Intensity Simultaneously Corrected (DISC), to deal with CT-CBCT DIR. DISC distinguishes itself from the original demons algorithm by performing an adaptive intensity correction step on the CBCT image at every iteration step of the demons registration. Specifically, the intensity correction of a voxel in CBCT is achieved by matching the first and the second moments of the voxel intensities inside a patch around the voxel with those on the CT image. It is expected that such a strategy can remove artifacts in the CBCT image, as well as ensuring the intensity consistency between the two modalities. DISC is implemented on computer graphics processing units (GPUs) in compute unified device architecture (CUDA) programming environment. The performance of DISC is evaluated on a simulated patient case and six clinical head-and-neck cancer patient data. It is found that DISC is robust against the CBCT artifacts and intensity inconsistency and significantly improves the registration accuracy when compared with the original demons.
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