Poor Oral Health and Inflammatory, Hemostatic, and Cardiac Biomarkers in Older Age: Results From Two Studies in the UK and USA
Poor Oral Health and Inflammatory, Hemostatic, and Cardiac Biomarkers in Older Age: Results From Two Studies in the UK and USA
复制标题
DOI：
10.1093/gerona/glaa096
复制
发表时间：
2021-02-01
影响因子：
5.1
通讯作者：
Ramsay, Sheena E.
中科院分区：
文献类型：
--
作者：
Kotronia, Eftychia;Wannamethee, S. Goya;Ramsay, Sheena E.
背景：我们调查了客观和主观口腔健康标记物与炎症、止血和心脏生物标记物在老年人中的关系。方法：横断面分析基于英国地区心脏研究(BRHS)和健康、老龄化和身体成分(HABC)研究(HABC研究)，该研究包括71-92岁的英国男性(n=2,147)和美国男性和女性(n=3,075)。口腔健康指标包括牙周病、牙数、口干。炎症生物标志物包括C-反应蛋白(CRP)、白介素6(IL-6)、组织型纤溶酶原激活物(t-PA)、血管性假血友病因子(VWF)、纤维蛋白D-二聚体、高敏肌钙蛋白T(HsTnT)和N端脑利钠肽原(NTproBNP)。结果：两组BRHS患者中，牙齿缺失与CRP优势比(ORs)(95%可信区间[CI])分别为1.31(1.02~1.68)；在HABC研究中，调整混杂因素后为1.40(1.13-1.75)。在HABC研究中，累积(=3)口腔健康问题与较高的CRP水平相关(OR[95%CI]=1.42[1.01-1.99])。在BRHS中，完全和部分牙齿缺失与止血因素有关，特别是与纤维蛋白D-二聚体的上三分之相关(OR[95%CI]=1.64[1.16-2.30]和1.37[1.05-1.77])。牙齿缺失和牙周病与hsTnT水平升高有关。结论：老年人口腔健康状况差，尤其是牙齿缺失，与某些炎症、止血和心脏生物标志物有关。前瞻性研究和干预试验可以帮助更好地了解口腔健康不良是否与炎症、止血和心脏生物标志物有因果关系。
Background: We examined the association of objective and subjective oral health markers with inflammatory, hemostatic, and cardiac biomarkers in older age.Methods: Cross-sectional analyses were based on the British Regional Heart Study (BRHS) comprising British men aged 71-92 years (n = 2,147), and the Health, Aging and Body Composition (HABC) Study comprising American men and women aged 71-80 years (n = 3,075). Oral health markers included periodontal disease, tooth count, dry mouth. Inflammatory biomarkers included C-reactive protein (CRP), interleukin-6 (IL-6) in both studies, and tissue plasminogen activator (t-PA), von Willebrand Factor (vWF), fibrin D-dimer, high-sensitivity Troponin T (hsTnT), and N-terminal pro-brain natriuretic peptide (NTproBNP) only in the BRHS.Results: In both studies, tooth loss, was associated with the top tertile of CRP-odds ratios (ORs) (95% confidence interval [CI]) are 1.31 (1.02-1.68) in BRHS; and 1.40 (1.13-1.75) in the HABC Study, after adjusting for confounders. In the HABC Study, cumulative (>= 3) oral health problems were associated with higher levels of CRP (OR [95% CI] = 1.42 [1.01-1.99]). In the BRHS, complete and partial tooth loss was associated with hemostatic factors, in particular with the top tertile of fibrin D-dimer (OR [95% CI] = 1.64 [1.16-2.30] and 1.37 [1.05-1.77], respectively). Tooth loss and periodontal disease were associated with increased levels of hsTnT.Conclusions: Poor oral health in older age, particularly tooth loss, was consistently associated with some inflammatory, hemostatic, and cardiac biomarkers. Prospective studies and intervention trials could help understand better if poor oral health is causally linked to inflammatory, hemostatic, and cardiac biomarkers.