STANDING STEADINESS MEASUREMENTS - EMPIRICAL SELECTION OF TESTING PROTOCOL AND OUTCOME MEASURES
STANDING STEADINESS MEASUREMENTS - EMPIRICAL SELECTION OF TESTING PROTOCOL AND OUTCOME MEASURES
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DOI：
10.1016/0892-0362(95)00023-2
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发表时间：
1995-11-01
影响因子：
2.9
通讯作者：
GERR, F
中科院分区：
文献类型：
--
作者：
LETZ, R;GERR, F
已经开发了多种测量神经毒性暴露影响的方法，并应用于暴露工人的流行病学研究。虽然损害平衡是一个常见的投诉工人暴露于神经毒物，只有少数研究已发表的站立稳定性的定量测量用于评估职业神经毒性。这些措施使用有限的可能原因包括对测试协议的评估和验证不足。目前的项目就是为了解决其中一些问题。具体而言，对正常受试者进行了两项研究，a）比较双脚并拢或双脚分开时的站立稳定性测量值，以及B）评估用于估计站立稳定性的许多潜在汇总测量值的可靠性。研究1对8名受试者进行连续2天的测试。结果表明，a）双脚并拢的位置比双脚分开的位置导致更大的系统方差，B）摇摆在60秒试验中系统地变化，c）三个60秒睁眼/闭眼试验对似乎没有提供比两对试验更多的信息。在研究2中，使用基于研究1的结果选择的程序，对30名受试者进行了两次检测，间隔2至7天。总的来说，观察到站立稳定性的几个总结措施中最可靠的是摇摆速度。
A variety of methods for measuring the effects of neurotoxic exposure have been developed and applied in epidemiologic studies of exposed workers. Although impairment of equilibrium is a common complaint among workers exposed to neurotoxicants, only a few studies have been published in which quantitative measurement of standing steadiness was used to assess occupational neurotoxicity. Possible reasons for limited use of these measures include inadequate evaluation and validation of testing protocols. The current project was undertaken to address some of these issues. Specifically, two studies of normal subjects were undertaken a) to compare standing steadiness measurements made with feet together or feet apart, and b) to assess the reliability of a number of potential summary measures for estimating standing steadiness. Study 1 was performed on eight subjects tested on 2 consecutive days. It demonstrated that a) a feet-together position resulted in greater systematic variance than a feet-apart position, b) sway varied systematically within 60-s trials, c) three 60-s eyes-open/eyes-closed trial pairs did not appear to provide more information than two pairs of trials. In Study 2, 30 subjects were tested on two occasions separated by 2 to 7 days using the procedure selected on the basis of the results from Study 1. Overall, the most reliable of several summary measures of standing steadiness was observed to be speed of sway.