Neurodevelopment of children exposed in utero to antidepressant drugs
Neurodevelopment of children exposed in utero to antidepressant drugs
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DOI：
10.1056/nejm199701233360404
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发表时间：
1997-01-23
影响因子：
158.5
通讯作者：
Koren, G
中科院分区：
文献类型：
--
作者：
Nulman, I;Rovet, J;Koren, G
背景：许多育龄妇女患有抑郁症，需要用三环抗抑郁药物或氟西汀等抑制血清素再吸收的药物进行治疗。这些药物是否影响胎儿神经发育尚不清楚。方法我们研究了80名母亲在怀孕期间服用过三环类抗抑郁药物的儿童，55名母亲在怀孕期间服用过氟西汀的儿童，以及84名母亲在怀孕期间未接触过任何已知对胎儿不利的药物的儿童。孩子们的整体智商和语言发展在出生后16到86个月之间通过与年龄相适应的贝利婴儿发展量表或麦卡锡儿童能力量表（智商）和雷纳尔发展语言量表进行评估。结果三环类抗抑郁药物组患儿的平均（+/-SD）总分为118+/-17分，氟西汀组患儿为117+/-17分，对照组患儿为115+/-14分。三组学生的语言成绩都差不多。在妊娠早期暴露于三环类抗抑郁药物或氟西汀的儿童和整个妊娠期间暴露于氟西汀的儿童的结果相似。三组儿童在气质、情绪、可唤起性、活动水平、注意力分散或行为问题上也没有显著差异。结论：子宫内暴露于三环抗抑郁药物或氟西汀不会影响学龄前儿童的全球通量表、语言发育或行为发育。(C) 1997年，马萨诸塞州医学会。
Background Many women of reproductive age have depression, necessitating therapy with either a tricyclic antidepressant drug or a drug, such as fluoxetine, that inhibits the reuptake of serotonin. Whether these drugs affect fetal neurodevelopment is not known.Methods We studied the children of 80 mothers who had received a tricyclic antidepressant drug during pregnancy, 55 children whose mothers had received fluoxetine during pregnancy, and 84 children whose mothers had not been exposed during pregnancy to any agent known to affect the fetus adversely. The children's global IQ and language development were assessed between 16 and 86 months of postnatal age by age-appropriate Bayley Scales of Infant Development or the McCarthy Scales of Children's Abilities (for IQ) and the Reynell Developmental Language Scales.Results The mean (+/-SD) global 10 scores were 118+/-17 in the children of mothers who received a tricyclic antidepressant drug, 117+/-17 in those whose mothers received fluoxetine, and 115+/-14 in those in the control group. The language scores were similar in all three groups. The results were similar in children exposed to a tricyclic antidepressant drug or fluoxetine during the first trimester and those exposed throughout pregnancy. There were also no significant differences in temperament, mood, arousability, activity level, distractibility, or behavior problems in the three groups of children.Conclusions In utero exposure to either tricyclic antidepressant drugs or fluoxetine does not affect global 10, language development, or behavioral development in preschool children. (C) 1997, Massachusetis Medical Society.