Changes in (markers of) bone metabolism during high dose corticosteroid pulse treatment in patients with rheumatoid arthritis
Changes in (markers of) bone metabolism during high dose corticosteroid pulse treatment in patients with rheumatoid arthritis
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DOI：
10.1136/ard.55.5.288
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发表时间：
1996-05-01
影响因子：
27.4
通讯作者：
Bijlsma, JWJ
中科院分区：
文献类型：
--
作者：
Lems, WF;Gerrits, MI;Bijlsma, JWJ
研究高剂量皮质类固醇脉冲治疗（3次200 mg地塞米松静脉注射8天）对17例活动性类风湿关节炎（RA）患者的钙和骨代谢的影响。方法通过测定血清碱性磷酸酶、骨钙素和I型前胶原羧基末端前肽（pro-I-CPP）浓度来定量骨形成。通过尿中钙、羟脯氨酸、（游离和总）吡啶啉（Pyr）的排泄和I型胶原羧基末端交联端肽（I-CTP）的血清浓度测定骨吸收。RA的疾病活动测定红细胞沉降率，C反应蛋白，和里奇和汤普森关节scores.Results-Disease活动最初是高的，皮质类固醇脉冲治疗和以下5周下降。骨钙素、碱性磷酸酶和pro-I-CPP浓度最初在正常范围内，而I-CTP、Dpyr和Pyr升高。骨钙素和pro-I-CPP浓度降低（p
Objective-To examine the effect of high dose corticosteroid pulse treatment (three times 200 mg dexamethasone intravenously in eight days) on calcium and bone metabolism in 17 consecutive patients with active rheumatoid arthritis (RA).Methods-Bone formation was quantified by measurement of serum alkaline phosphatase, osteocalcin, and carboxyterminal propeptide of type I procollagen (pro-I-CPP) concentrations. Bone resorption was measured by urinary excretion of calcium, hydroxyproline, (free and total) pyridinoline (Pyr), and serum concentrations of the carboxyterminal cross linked telopeptide of type I collagen (I-CTP). Disease activity of RA was measured by erythrocyte sedimentation rate, C reactive protein, and Ritchie and Thompson joint scores.Results-Disease activity was initially high, and decreased during corticosteroid pulse treatment and the following five weeks. Osteocalcin, alkaline phosphatase, and pro-I-CPP concentrations were initially within normal limits, while I-CTP, Dpyr, and Pyr were increased. Osteocalcin and pro-I-CPP concentrations decreased (p