Behavioral inhibition of light-induced circadian phase resetting is phase and serotonin dependent
Behavioral inhibition of light-induced circadian phase resetting is phase and serotonin dependent
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DOI：
10.1016/s0006-8993(97)01269-9
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发表时间：
1998-03-09
期刊：
影响因子：
2.9
通讯作者：
Antle, MC
中科院分区：
文献类型：
--
作者：
Mistlberger, RE;Antle, MC
叙利亚仓鼠的昼夜节律可以通过主观夜间的光照和主观白天引起的一轮轮转而发生相移。通过比较 15 分钟、50 勒克斯光脉冲的相移，检查光刺激和行为刺激之间的相互作用，并在光暴露前 30 分钟并通过光暴露延伸，在有或没有由限制在新型轮子上引起的跑步中。在持续黑暗诱导的平均 80 分钟相移的第一个晚上，黑暗开始后 6 小时发出光脉冲。车轮运行使这些变化平均减弱 45% (p < 0.01)。天黑开始后 1 小时或 2.25 小时的光脉冲分别引起平均 50 分钟和 20 分钟的相延迟变化，且不受刺激跑步的影响。在所有 3 个时间点，对新颖车轮的显着跑步反应都很明显，但在深夜的两个时间点对车轮限制的反应更大。在清晨或深夜单独进行刺激跑步并没有产生显着的相移。通过用通用 5HT1 拮抗剂米角林（2 mg/kg i.p.）进行预处理，可以防止深夜时相提前到光的行为衰减。麦角林并没有显着减弱新型轮子的运行。这些结果表明，行为对光诱导相移的调节是相位依赖性的，并且可能涉及昼夜节律系统内血清素的直接或间接作用。 (C) 1998 Elsevier Science B.V.
Circadian rhythms in Syrian hamsters can be phase shifted by light exposure during the subjective night and by a bout of wheel running induced during the subjective day. Interactions between photic and behavioral stimuli were examined by comparing phase shifts to 15 min, 50 lux Light pulses with and without a bout of running induced by confinement to a novel wheel 30 min prior to and extending through light exposure. Light pulses 6 h after dark onset on the first night of constant dark induced phase advance shifts averaging 80 min. Wheel running attenuated these shifts by 45% on average(p < 0.01). Light pulses 1 h or 2.25 h after dark onset induced phase delay shifts averaging 50 min and 20 min, respectively, that were not affected by stimulated running. A significant running response to the novel wheel was evident at all 3 time points, but was greater to wheel confinement at both times early in the night. Stimulated running alone early or late in the night did not produce significant phase shifts. Behavioral attenuation of phase advances to light late in the night was prevented by pretreatment with the general 5HT1 antagonist metergoline (2 mg/kg i.p.). Metergoline did not significantly attenuate running in novel wheels. These results indicate that modulation of Light-induced phase shifts by behavior is phase dependent and may involve direct or indirect actions of serotonin within the circadian system. (C) 1998 Elsevier Science B.V.