Development of a small prototype for a proof-of-concept of OpenPET imaging
Development of a small prototype for a proof-of-concept of OpenPET imaging
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DOI：
10.1088/0031-9155/56/4/015
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发表时间：
2011-02
影响因子：
3.5
通讯作者：
T. Yamaya;E. Yoshida;T. Inaniwa;S. Sato;Yasunori Nakajima;H. Wakizaka;D. Kokuryo;Atsushi B. Tsuji;T. Mitsuhashi;H. Kawai;H. Tashima;F. Nishikido;N. Inadama;H. Murayama;H. Haneishi;M. Suga;S. Kinouchi
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文献类型：
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作者：
T. Yamaya;E. Yoshida;T. Inaniwa;S. Sato;Yasunori Nakajima;H. Wakizaka;D. Kokuryo;Atsushi B. Tsuji;T. Mitsuhashi;H. Kawai;H. Tashima;F. Nishikido;N. Inadama;H. Murayama;H. Haneishi;M. Suga;S. Kinouchi
OpenPET 几何结构是我们的新想法，用于可视化两个探测器环之间的物理开放空间。在本文中，我们开发了第一个小型原型来展示 OpenPET 成像的概念验证。两个直径为 110 mm、轴向长度为 42 mm 的探测器环放置时间隙为 42 mm。通过体模研究证实了基本成像性能；开放式成像的实现是以轴向分辨率略有损失和灵敏度损失24%为代价的。为了验证 PET 图像引导放射治疗的概念，我们在千叶的重离子医疗加速器中进行了 11C 放射性束照射的束内测试，以可视化停在体模中的初级粒子的原位分布。我们表明获得了与剂量分布相对应的 PET 图像。为了对实时多模态成像进行初步概念验证，我们用 18F-FDG 测量了接种肿瘤的小鼠，并在 PET 测量过程中通过在环形间隙中插入数码相机来拍摄小鼠体表的光学图像。我们确认间隙中的肿瘤清晰可见。结果还显示了轴向视场（FOV）的扩展效果；最初仅覆盖 84 毫米轴向 FOV 的探测器获得了 126 毫米的大轴向 FOV。总之，我们的初步成像研究表明 OpenPET 具有良好的性能。
The OpenPET geometry is our new idea to visualize a physically opened space between two detector rings. In this paper, we developed the first small prototype to show a proof-of-concept of OpenPET imaging. Two detector rings of 110 mm diameter and 42 mm axial length were placed with a gap of 42 mm. The basic imaging performance was confirmed through phantom studies; the open imaging was realized at the cost of slight loss of axial resolution and 24% loss of sensitivity. For a proof-of-concept of PET image-guided radiation therapy, we carried out the in-beam tests with 11C radioactive beam irradiation in the heavy ion medical accelerator in Chiba to visualize in situ distribution of primary particles stopped in a phantom. We showed that PET images corresponding to dose distribution were obtained. For an initial proof-of-concept of real-time multimodal imaging, we measured a tumor-inoculated mouse with 18F-FDG, and an optical image of the mouse body surface was taken during the PET measurement by inserting a digital camera in the ring gap. We confirmed that the tumor in the gap was clearly visualized. The result also showed the extension effect of an axial field-of-view (FOV); a large axial FOV of 126 mm was obtained with the detectors that originally covered only an 84 mm axial FOV. In conclusion, our initial imaging studies showed promising performance of the OpenPET.