FDG imaging of lung nodules: a phantom study comparing SPECT, camera-based PET, and dedicated PET.
FDG imaging of lung nodules: a phantom study comparing SPECT, camera-based PET, and dedicated PET.
复制标题
肺结节 FDG 成像：一项比较 SPECT、基于相机的 PET 和专用 PET 的模型研究。
作者：
R. Coleman;C. Laymon;T. Turkington
目的
通过使用衰减校正和非衰减校正的511-keV单光子发射计算机断层扫描（SPECT）、基于相机的正电子发射断层扫描（PET）和专用PET成像，评价真实胸部体模中模拟肺结节的2-[氟-18]氟-2-脱氧-D-葡萄糖（FDG）成像。
材料和方法
将直径为6、10、13和22 mm的球体放置在拟人胸部体模的肺中以模拟结节。根据衰减校正专用FDG PET扫描分析得出的肺、结节、胸壁和纵隔中的平均放射性核素浓度，这些结构充满氟-18活性。通过对比度和信噪比对图像集进行视觉和定量评价。
结果
衰减校正降低了肺中的人为高表观摄取，恢复了结节的球形，并提供了具有适当强度的准确外部身体轮廓。专用PET描绘了所有四个结节，基于相机的PET描绘了三个最大的结节，而SPECT描绘了两个最大的结节。衰减校正图像的病变对比度优于非衰减校正图像。通过衰减校正，信噪比普遍得到改善。
结论
衰减校正导致图像中的许多变化，并改善病变检测。
PURPOSE
To evaluate 2-[fluorine-18]fluoro-2-deoxy-D-glucose (FDG) imaging of simulated lung nodules in a realistic chest phantom by using attenuation-corrected and non-attenuation-corrected 511-keV single photon emission computed tomography (SPECT), camera-based positron emission tomography (PET), and dedicated PET imaging.
MATERIALS AND METHODS
Spheres with diameters of 6, 10, 13, and 22 mm were placed in the lungs of an anthropomorphic chest phantom to simulate nodules. The lungs, nodules, chest wall, and mediastinum were filled with fluorine-18 activities based on the average radionuclide concentrations in those structures from analysis of attenuation-corrected dedicated FDG PET scans. The image sets were evaluated visually and quantitatively by using contrast and signal-to-noise ratios.
RESULTS
Attenuation correction reduced the artificially high apparent uptake in the lungs, restored the spherical shape to the nodules, and provided an accurate outer body contour with appropriate intensity. Dedicated PET depicted all four nodules, camera-based PET depicted the three largest nodules, and SPECT depicted the two largest nodules. Lesion contrast was better on the attenuation-corrected images than on the non-attenuation-corrected images. The signal-to-noise ratio generally was improved with attenuation correction.
CONCLUSION
Attenuation correction results in many changes in the images and improves lesion detection.
DOI：
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发表时间：
1987-11
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
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作者：
M. Daube-Witherspoon;G. Muehllehner
通讯作者：
M. Daube-Witherspoon;G. Muehllehner