Acute exacerbations in severe COLD patients. Treatment using positive pressure ventilation by nasal mask.
Acute exacerbations in severe COLD patients. Treatment using positive pressure ventilation by nasal mask.
复制标题
严重感冒患者急性加重。
作者：
Caterina Foglio;M. Vitacca;Armido Quadri;Simonetta Scalcini;Silvia Marangoni;N. Ambrosino
我们回顾性评价了49例急性加重期COLD患者经鼻面罩间歇正压通气治疗方案的临床有效性。根据成功耐受NIPPV初步试验的能力，患者接受标准治疗加NIPPV（25例）或单独ST（24例）。ST包括药物、氧气和物理治疗。NIPPV由容量循环呼吸机在控制模式下输送，每周连续5天，每天至少4小时，持续3周。基线与治疗10天和21天后测量值的比较显示，两组的PaO2和PaCO2均显著改善。治疗21天后，两组的VC、FEV1、吸气肌力和呼吸困难均显著改善。在治疗的任何时间，组间均无显著差异。我们的结论是，在感冒急性加重期，使用NIPPV的治疗方案并不比单独使用ST更有效。
We retrospectively evaluated the clinical effectiveness of a treatment schedule with intermittent positive pressure ventilation via nasal mask in 49 patients with acute exacerbations of COLD. According to the ability to successfully tolerate a preliminary trial with NIPPV, patients were submitted either to standard treatment plus NIPPV (25 patients) or to ST alone (24 patients). The ST consisted of medical, oxygen and physical therapy. The NIPPV was delivered by a volume cycled ventilator in control mode at least 4 h a day for five consecutive days a week, for three weeks. Comparison of baseline with measurements performed after 10 and 21 days of treatment respectively showed a significant improvement in PaO2 and in PaCO2 in both groups. After 21 days of treatment, VC, FEV1, inspiratory muscle strength, and dyspnea significantly improved in both groups. No significant difference was found between groups at any time of treatment. We conclude that the treatment schedule of NIPPV used is not more effective than ST alone in acute exacerbations of COLD.