Gating of Sensory Input at Spinal and Cortical Levels during Preparation and Execution of Voluntary Movement
Gating of Sensory Input at Spinal and Cortical Levels during Preparation and Execution of Voluntary Movement
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DOI：
10.1523/jneurosci.4958-11.2012
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发表时间：
2012-01-18
影响因子：
5.3
通讯作者：
Fetz, Eberhard E.
中科院分区：
文献类型：
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作者：
Seki, Kazuhiko;Fetz, Eberhard E.
所有的身体运动都会刺激外周感受器，通过传入反馈激活大脑和脊髓中的神经元。在运动过程中，这些传入信号在中枢神经系统内如何处理是运动控制中的一个关键问题。我们研究了猴子在执行指令延迟任务时脊髓、初级躯体感觉和运动皮层以及运动前皮层的皮肤感觉诱发电位。从皮肤感受器传入的输入抑制在几个层次上的任务依赖性的方式。我们发现了两种抑制。首先，在脊髓和所有三个皮层区域观察到主动肢体运动期间的抑制。这种抑制是由自下而上和自上而下的门控机制引起的。第二，在准备即将到来的运动，诱发反应被抑制专门在运动皮质区和抑制的幅度与随后的运动的反应时间。这种抑制可以通过自上而下的门控机制来诱导，以促进即将到来的运动的准备和执行。
All bodily movements stimulate peripheral receptors that activate neurons in the brain and spinal cord through afferent feedback. How these reafferent signals are processed within the CNS during movement is a key question in motor control. We investigated cutaneous sensory-evoked potentials in the spinal cord, primary somatosensory and motor cortex, and premotor cortex in monkeys performing an instructed delay task. Afferent inputs from cutaneous receptors were suppressed at several levels in a task-dependent manner. We found two types of suppression. First, suppression during active limb movement was observed in the spinal cord and all three cortical areas. This suppression was induced by both bottom-up and top-down gating mechanisms. Second, during preparation for upcoming movement, evoked responses were suppressed exclusively in the motor cortical areas and the magnitude of suppression was correlated with the reaction time of the subsequent movement. This suppression could be induced by a top-down gating mechanism to facilitate the preparation and execution of upcoming movement.