Amplified parabrachial nucleus activity in a rat model of trigeminal neuropathic pain.
Amplified parabrachial nucleus activity in a rat model of trigeminal neuropathic pain.
复制标题
三叉神经病理性疼痛大鼠模型中臂旁核活动增强。
DOI：
10.1016/j.ynpai.2018.02.002
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Keller,Asaf
中科院分区：
文献类型：
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作者：
Uddin,Olivia;Studlack,Paige;Akintola,Titilola;Raver,Charles;Castro,Alberto;Masri,Radi;Keller,Asaf
臂旁 (PB) 复合体介导情感/情绪疼痛通路中的上行伤害感受信号和下行疼痛调节信息。我们假设 PB 过度活跃会影响大鼠三叉神经损伤后的慢性疼痛行为。使用眶下神经慢性压迫性损伤（CCI-ION）模型诱导神经性疼痛后，大鼠表现出自发的疼痛标记和机械性痛觉过敏，其范围超出了受伤神经的感受野。与假手术相比，CCI-ION 大鼠记录的 PB 神经元活性增强，表现为对感觉刺激的反应明显更长。这些发现表明慢性神经性疼痛与 PB 过度活跃有关。
The parabrachial (PB) complex mediates both ascending nociceptive signaling and descending pain modulatory information in the affective/emotional pain pathway. We hypothesized that PB hyperactivity influences chronic pain behavior after trigeminal nerve injury in rats. Following induction of neuropathic pain using the chronic constriction injury of the infraorbital nerve (CCI-ION) model, rats displayed spontaneous markers of pain and mechanical hyperalgesia extending beyond the receptive field of the injured nerve. PB neurons recorded from rats with CCI-ION displayed amplified activity, manifesting as significantly longer responses to sensory stimuli, compared to shams. These findings suggest that chronic neuropathic pain involves PB hyperactivity.