The cytoneme connection: direct long-distance signal transfer during development
The cytoneme connection: direct long-distance signal transfer during development
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DOI：
10.1242/dev.174607
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发表时间：
2019-05-01
期刊：
影响因子：
4.6
通讯作者：
Guerrero, Isabel
中科院分区：
文献类型：
--
作者：
Gonzalez-Mendez, Laura;Gradilla, Ana-Citlali;Guerrero, Isabel
在发育过程中，专门的细胞产生信号，这些信号分布在接收细胞之间，以诱导各种细胞行为和组织组织。最近的研究强调了细胞线，一种携带配体和/或受体复合体的专门信号丝状载体，在信号分散中起到了作用。在这本初级读本中，我们讨论了细胞素的动态调节如何促进复杂环境中的信号传递。我们评估了细胞素形成、功能和调节机制的最新证据，并假设细胞素膜之间的接触促进了作为一种新型突触(形态发生突触)的信号传递。最后，我们反思与理解细胞素生物学相关的基本未回答的问题。
During development, specialized cells produce signals that distribute among receiving cells to induce a variety of cellular behaviors and organize tissues. Recent studies have highlighted cytonemes, a type of specialized signaling filopodia that carry ligands and/or receptor complexes, as having a role in signal dispersion. In this Primer, we discuss how the dynamic regulation of cytonemes facilitates signal transfer in complex environments. We assess recent evidence for the mechanisms for cytoneme formation, function and regulation, and postulate that contact between cytoneme membranes promotes signal transfer as a new type of synapse (morphogenetic synapsis). Finally, we reflect on the fundamental unanswered questions related to understanding cytoneme biology.