Nanostructured Thermoresponsive Surfaces Engineered via Stable Immobilization of Smart Nanogels with Assistance of Polydopamine.
Nanostructured Thermoresponsive Surfaces Engineered via Stable Immobilization of Smart Nanogels with Assistance of Polydopamine.
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DOI：
10.1021/acsami.8b20395
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发表时间：
2018-11
影响因子：
9.5
通讯作者：
Lei Zhang;Zhuang Liu;Lu-Yue Liu;Jun-li Pan;F. Luo;Chao Yang;Rui Xie;Xiao‐Jie Ju;Wei Wang-Wei-Wa
中科院分区：
文献类型：
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作者：
Lei Zhang;Zhuang Liu;Lu-Yue Liu;Jun-li Pan;F. Luo;Chao Yang;Rui Xie;Xiao‐Jie Ju;Wei Wang-Wei-Wa
以纳米结构为特征的热敏表面在生物和化学领域有着广泛的潜在应用。在这里，我们报告了在多多巴胺的协助下，通过稳定固定热响应纳米凝胶来设计的纳米结构热响应表面。结果表明，聚N-异丙基丙烯酰胺(PNIPAM)纳米凝胶表面的聚多巴胺薄层几乎不影响纳米凝胶的热响应性能。通过毛细管内流体剪切实验，定量研究了不同pH条件下固定在基片表面的热敏纳米凝胶的稳定性，表征结果表明，基片表面多聚多巴胺层与热敏纳米凝胶之间的强相互作用力严重依赖于多巴胺分子的氧化状态。利用所提出的策略，在二维和三维衬底表面分别制备了固定有PNIPAM纳米凝胶的热响应性纳米结构表面，以实现智能细胞培养板和智能门控膜，从而展示了纳米结构热响应性表面的广泛应用。
Thermoresponsive surfaces featured with nanostructures have found wide potential applications in biological and chemical fields. Herein, we report nanostructured thermoresponsive surfaces engineered via stable immobilization of thermoresponsive nanogels with the assistance of polydopamine. The results show that the thin layer of polydopamine on the poly( N-isopropylacrylamide) (PNIPAM) nanogels nearly does not affect the thermoresponsive property of the nanogels. The stability of the thermoresponsive nanogels on the substrate surfaces immobilized under different pH conditions of dopamine solutions are quatitively studied by fluid shearing experiments inside capillaries, and the characterization results show that the strong interaction forces between the polydopamine layer on the substrate surfaces and the thermoresponsive nanogels are heavily dependent on the oxidation state of the dopamine molecules. With the proposed strategy, thermoresponsive nanostructured surfaces immobilized with PNIPAM nanogels on two-dimensional and three-dimensional substrate surfaces are generated to achieve smart cell culture plates and smart gating membranes, respectively, which demonstrate versatile applications of the nanostructured thermoresponsive surfaces.