Access to 5(6→7)abeo-Steroids through Benzilic Acid Rearrangement of i-Steroids
Access to 5(6→7)abeo-Steroids through Benzilic Acid Rearrangement of i-Steroids
复制标题
通过 i-类固醇的苯甲酸重排获得 5(6→7)abeo-类固醇
DOI：
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发表时间：
2018
期刊：
影响因子：
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通讯作者：
P. Heretsch
中科院分区：
文献类型：
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作者：
F. Noack;Bence Hartmayer;P. Heretsch
通过对i-甾体酮的二苯甲酸重排及随后的开环反应，可得到5（6→7）个非甾体。通过几个实例证明了官能团耐受性，包括具有额外烯属基团的底物。该方法开辟了一条潜在的路线，从丰富的类固醇原料，如麦角甾醇，合成复杂的天然产物，如茄酸。
Abstract Benzilic acid rearrangement of i-steroid ketones and their subsequent opening gives access to 5(6→7)abeo-steroids. The functional group tolerance is demonstrated by several examples, including substrates with additional olefinic groups. The method opens a potential route to the synthesis of complex natural products such as solanioic acid from abundant steroid starting materials like ergosterol.
影响因子：
2.9
作者：
Cygan NK;Scheinost JC;Butters TD;Wentworth P Jr
通讯作者：
Wentworth P Jr