Research progress on the regulation of tumor initiation and development by the forkhead box Q1 gene
Research progress on the regulation of tumor initiation and development by the forkhead box Q1 gene
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叉头盒Q1基因调控肿瘤发生发展的研究进展
DOI：
10.4103/jcrt.jcrt_701_17
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发表时间：
2018-01
期刊：
影响因子：
--
通讯作者：
Guo Q.
中科院分区：
文献类型：
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作者：
Tang H;Zhang J;Guo Q.
转录因子叉头盒Q1(FOXQ1)是叉头盒超家族成员之一，参与多种生物学过程，在肿瘤的发生发展中发挥重要作用。FOXQ1蛋白通过与靶基因启动子结合或与其他转录因子相互作用间接激活靶基因的转录。FOXQ1通过促进上皮-间充质转化、调节细胞周期、促进细胞增殖、调节衰老相关炎症、激活多种细胞信号通路，影响多种肿瘤的发生、发展、侵袭和转移。本文就FOXQ1基因在肿瘤发生发展中可能的分子机制作一综述。应用计算机检索PubMed相关文献，检索词“Forkhead box Q1”和“Tumor”，限定文章语言种类为“Forkhead box Q1”，并对FOXQ1基因的生物学功能及FOXQ1直接调控靶基因转录的参考文献进行综述。
Transcription factor forkhead box Q1 (FOXQ1), a member of the forkhead box superfamily, has been involved in various biological processes and plays important roles in tumor initiation and progression. The FOXQ1 protein activated transcription of target genes directly by binding to the promoters of target genes or indirectly by interacting with other transcription factors. FOXQ1 affected the initiation, progression, invasion, and metastasis of many kinds of tumor by promoting the epithelial–mesenchymal transition, regulating cell cycle, promoting cell proliferation, regulating senescence-associated inflammation, and activating many cellular signal pathways. In this review, we have focused on the possible molecular mechanisms for FOXQ1 gene in tumor initiation and progression. Medline literature review related to this subject was performed by the electronically retrieval with the keywords “forkhead box Q1” and “tumor” on PubMed for including previous publications, and then, it further reviewed reference articles on the biological function of FOXQ1 gene and target genes transcription directly regulated by FOXQ1.