THE DROSOPHILA NEUROGENIC GENE NEURALIZED ENCODES A NOVEL PROTEIN AND IS EXPRESSED IN PRECURSORS OF LARVAL AND ADULT NEURONS
THE DROSOPHILA NEUROGENIC GENE NEURALIZED ENCODES A NOVEL PROTEIN AND IS EXPRESSED IN PRECURSORS OF LARVAL AND ADULT NEURONS
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DOI：
10.1002/j.1460-2075.1991.tb07848.x
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发表时间：
1991-10-01
期刊：
影响因子：
11.4
通讯作者：
JAN, YN
中科院分区：
文献类型：
--
作者：
BOULIANNE, GL;DELACONCHA, A;JAN, YN
神经化属于一组与果蝇神经发生有关的基因。功能突变的丧失会导致神经元的过度生产，损害表皮组织。我们克隆了这个神经化的基因，并检测了它在发育过程中的表达模式。最初在胚胎发生的神经性外胚层中观察到表达，后来在神经母细胞中观察到表达。此外，在成像盘发育过程中的感觉前体细胞中也发现了转录本。其他表达神经化的组织包括胚胎中胚层和卵巢中特定的滤泡细胞。预测的神经化基因产物是一种高度碱性的蛋白质，具有一个新的基序，与核酸结合蛋白中的基序有一些相似之处。该基序的前半部分与同源异型盒的前半部分序列相似，而后半部分类似于细菌阻遏物的螺旋-转弯-螺旋结构。
neuralized belongs to a group of genes involved in neurogenesis in Drosophila. Loss of function mutations lead to an overproduction of neurons at the expense of epidermal tissues. We have cloned the neuralized locus and examined its expression pattern during development. Expression is initially observed during embryogenesis in the neurogenic ectoderm and later in neuroblasts. In addition, transcripts are also found in sensory precursor cells during imaginal disc development. Other tissues that express neuralized include the embryonic mesoderm and specific follicle cells in the ovary. The predicted neuralized gene product is a highly basic protein with a novel motif that bears some resemblance to those found in nucleic acid-binding proteins. The first half of this motif has sequence similarity to the first half of a homeobox whereas the second half is similar to the helix-turn-helix structure of bacterial repressors.