Noninvasive measures of liver fibrosis
Noninvasive measures of liver fibrosis
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DOI：
10.1002/hep.21046
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发表时间：
2006-02-01
期刊：
影响因子：
13.5
通讯作者：
Bissell, DM
中科院分区：
文献类型：
--
作者：
Rockey, DC;Bissell, DM
随着肝纤维化新疗法的发展，需要对肝纤维化进行无创测量，以帮助管理慢性肝脏疾病患者。虽然肝活检是目前和历史悠久的测量肝纤维化的金标准，但由于其费用和发病率，它不适合频繁监测，并且其准确性受到采样变化的影响。在目前的写作中，血清标记物和成像方法是可用的，并且越来越多地用作活检的替代品。然而，关于其适应症，准确性和成本效益仍然存在许多问题，在广泛使用之前需要进行更多的调查。开发安全、廉价、可靠的非侵入性纤维化测量工具仍然是临床肝病学的研究重点。
As novel therapies for liver fibrosis evolve, non-invasive measurement of liver fibrosis will be required to help manage patients with chronic liver disease. Although liver biopsy is the current and time-honored gold standard for measurement of liver fibrosis, it is poorly suited to frequent monitoring because of its expense and morbidity, and its accuracy suffers from sampling variation. At the current writing, serum markers and imaging methods are available and increasingly in use as alternatives to biopsy. However, many questions remain about their indications, accuracy, and cost-effectiveness, and more investigation is required before they are put into widespread use. The development of safe, inexpensive, and reliable noninvasive fibrosis measurement tools remains a research priority in clinical hepatology.