Impaired decision-making and selective cortical frontal thinning in Cushing's syndrome
Impaired decision-making and selective cortical frontal thinning in Cushing's syndrome
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DOI：
10.1111/cen.12564
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发表时间：
2014-12-01
影响因子：
3.2
通讯作者：
Resmini, Eugenia
中科院分区：
文献类型：
--
作者：
Crespo, Iris;Esther, Granell-Moreno;Resmini, Eugenia
背景和目的库欣综合征(CS)是由糖皮质激素过多引起的。这种皮质醇过多会损害前额叶皮质，这是众所周知的在决策中很重要的部分。研究对象和方法对35例CS患者(27例治愈，8例内科治疗)和35例对照组进行了艾奥瓦州赌博任务(IGT)和3Tesla磁共振成像(MRI)的皮质厚度评估。IGT评估决策，包括测试期间的策略和学习。使用Freesurfer软件工具在MRI上测量皮质厚度，包括全脑分析。结果内科治疗和治愈的CS患者之间没有差异。与对照组相比，他们提出了一种不同的决策策略，选择了更少数量的更安全的卡片(P
Context and objectiveCushing's syndrome (CS) is caused by a glucocorticoid excess. This hypercortisolism can damage the prefrontal cortex, known to be important in decision-making. Our aim was to evaluate decision-making in CS and to explore cortical thickness.Subjects and methodsThirty-five patients with CS (27 cured, eight medically treated) and thirty-five matched controls were evaluated using Iowa gambling task (IGT) and 3 Tesla magnetic resonance imaging (MRI) to assess cortical thickness. The IGT evaluates decision-making, including strategy and learning during the test. Cortical thickness was determined on MRI using freesurfer software tools, including a whole-brain analysis.ResultsThere were no differences between medically treated and cured CS patients. They presented an altered decision-making strategy compared to controls, choosing a lower number of the safer cards (P