Tying trafficking to fusion and fission at the mighty mitochondria.
Tying trafficking to fusion and fission at the mighty mitochondria.
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DOI：
10.1111/tra.12573
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发表时间：
2018-08
期刊：
影响因子：
--
通讯作者：
Caplan S
中科院分区：
文献类型：
--
作者：
Farmer T;Naslavsky N;Caplan S
线粒体是一种独特的细胞器，是细胞能量所需的三磷酸腺苷 (ATP) 生成的主要场所。然而，线粒体在细胞凋亡和坏死以及与应激调节、自噬、脂质合成和钙储存相关的多种关键功能中也发挥着重要作用。人们越来越认识到线粒体功能是由其膜融合和裂变的动力学调节的。较长的融合线粒体最适合 ATP 生成，而线粒体的裂变则促进线粒体自噬和细胞分裂。尽管线粒体稳态对于此类关键的细胞事件具有重要意义，但线粒体融合和裂变的复杂调节仍只得到部分了解。直到最近，才发现了一种线粒体裂变蛋白。此外，研究人员直到现在才转向解决调节线粒体融合和裂变蛋白的上游机制。在此，我们回顾了参与线粒体融合和裂变的已知 GTP 酶，同时也重点介绍了解决这些 GTP 酶调节机制的最新研究。特别是，我们提请注意大量新文献，这些文献将内吞调节蛋白（例如逆转录体 VPS35 货物选择复合物亚基）与线粒体稳态联系起来。这些最近的研究表明，内吞途径和线粒体途径之间的关系和交叉调节可能比之前假设的更为广泛。
The mitochondrion is a unique organelle that serves as the main site of adenosine triphosphate (ATP) generation needed for energy in the cell. However, mitochondria also play essential roles in cell death through apoptosis and necrosis, as well as a variety of crucial functions related to stress regulation, autophagy, lipid synthesis, and calcium storage. There is a growing appreciation that mitochondrial function is regulated by the dynamics of its membrane fusion and fission; longer, fused mitochondria are optimal for ATP generation, whereas fission of mitochondria facilitates mitophagy and cell division. Despite the significance of mitochondrial homeostasis for such crucial cellular events, the intricate regulation of mitochondrial fusion and fission is only partially understood. Until very recently, only a single mitochondrial fission protein had been identified. Moreover, only now have researchers turned to address the upstream machinery that regulates mitochondrial fusion and fission proteins. Herein, we review the known GTPases involved in mitochondrial fusion and fission, but also highlight recent studies that address the mechanisms by which these GTPases are regulated. In particular, we draw attention to a substantial new body of literature linking endocytic regulatory proteins, such as the retromer VPS35 cargo selection complex subunit, to mitochondrial homeostasis. These recent studies suggest that relationships and cross-regulation between endocytic and mitochondrial pathways may be more widespread than previously assumed.
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DOI：
10.1083/jcb.200911024
发表时间：
2010-08-09
期刊：
The Journal of cell biology
影响因子：
--
作者：
Friedman JR;Webster BM;Mastronarde DN;Verhey KJ;Voeltz GK
通讯作者：
Voeltz GK
影响因子：
3.5
作者：
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影响因子：
4.2
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DOI：
10.1083/jcb.200211046
发表时间：
2003-01-20
期刊：
The Journal of cell biology
影响因子：
--
作者：
Chen H;Detmer SA;Ewald AJ;Griffin EE;Fraser SE;Chan DC
通讯作者：
Chan DC
影响因子：
4
作者：
Farmer, Trey;Reinecke, James B.;Caplan, Steve
通讯作者：
Caplan, Steve