CUB domains are not required for OVCH2 function in sperm maturation in the mouse epididymis.
CUB domains are not required for OVCH2 function in sperm maturation in the mouse epididymis.
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DOI：
10.1111/andr.13508
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发表时间：
2023-08
期刊：
影响因子：
4.5
通讯作者：
Katarzyna Kent;K. Nozawa;Courtney Sutton;Frey Daniel;M. Ikawa;Thomas X. Garcia;M. Matzuk
中科院分区：
文献类型：
--
作者：
Katarzyna Kent;K. Nozawa;Courtney Sutton;Frey Daniel;M. Ikawa;Thomas X. Garcia;M. Matzuk
Ovochymase 2（Ovch 2）是一种附睾特异性基因，是男性生育所必需的。虽然已经确定了男性生育力所需的大量生殖道特异性基因，但OVCH 2是迄今为止第一种男性生育力所需的蛋白质，其含有位于蛋白质C末端串联的补体C1 r/C1 s，Uegf，Bmp 1（CUB）结构域。确定这一独特的结构域的功能意义，在更好地理解生育和不孕症，并作为一个潜在的避孕目标的影响。
Ovochymase 2 (Ovch2) is an epididymis‐specific gene that is required for male fertility. While a multitude of reproductive tract‐specific genes required for male fertility have been identified, OVCH2 is thus far the first protein required for male fertility that contains Complement C1r/C1s, Uegf, Bmp1 (CUB) domains located in tandem in the C‐terminus of the protein. Identifying the functional significance of this unique domain has implications in better understanding fertility and infertility and as a potential contraceptive target.