Links between cancer stem cells and epithelial-mesenchymal transition.
Links between cancer stem cells and epithelial-mesenchymal transition.
复制标题
癌症干细胞与上皮间质转化之间的联系。
DOI：
10.2147/ott.s91863
复制
发表时间：
2015
影响因子：
4
通讯作者：
Tang YL
中科院分区：
文献类型：
--
作者：
Wang SS;Jiang J;Liang XH;Tang YL
The epithelial–mesenchymal transition (EMT) has been reported to be an important program that is often activated during the process of cancer invasion and metastasis. Cancer stem cells (CSCs) that can initiate and maintain cancer are also involved in invasion and metastasis of cancer. Recently, insights into the molecular mechanisms and functional features of mesenchymal cells have been greatly colored by findings that some of them have been endowed with the self-renewal trait associated with normal tissue stem cells and CSCs. Among cancer cells experiencing EMT, only some of the most competent CSCs will succeed in planting in another organ. In this paper, we review the molecular mechanism behind the link of EMT and CSCs in cancer progression.
