Origin of dendritic cells in peripheral lymphoid organs of mice
Origin of dendritic cells in peripheral lymphoid organs of mice
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DOI：
10.1038/ni1462
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发表时间：
2007-06-01
影响因子：
30.5
通讯作者：
Nussenzweig, Michel
中科院分区：
文献类型：
--
作者：
Liu, Kang;Waskow, Claudia;Nussenzweig, Michel
抛物性实验表明，即使长期通过抛物线率连接后，树突状细胞（DC）也无法平衡小鼠之间的平衡，这表明DC是源自自我更新的祖细胞，这些祖细胞分裂了原位。但是，在这里，我们发现，与抛物线的小鼠之间的DC交换不平等，反映出由于循环短的半衰期，血液中直流前体的分布不均匀。 DC在10至14天的脾脏或淋巴结中仅接受了有限数量的划分，并以每小时近4,300个细胞的速度从血源性前体中补充。女儿DC呈现了其祖细胞捕获的抗原，这表明外周淋巴器官中的DC分裂可以延长体内抗原表现的持续时间。
Parabiosis experiments demonstrating that dendritic cells (DCs) do not equilibrate between mice even after prolonged joining by parabiosis have suggested that DCs are derived from self-renewing progenitors that divide in situ. However, here we found that unequal exchange of DCs between mice joined by parabiosis reflected uneven distribution of DC precursors in blood due to their short half-life in circulation. DCs underwent only a limited number of divisions in the spleen or lymph nodes over a 10- to 14-day period and were replenished from blood-borne precursors at a rate of nearly 4,300 cells per hour. Daughter DCs presented antigens captured by their progenitors, suggesting that DC division in peripheral lymphoid organs can prolong the duration of antigen presentation in vivo.