Nigellamines A3, A4, A5, and C, new dolabellane-type diterpene alkaloids, with lipid metabolism-promoting activities from the Egyptian medicinal food black cumin
Nigellamines A3, A4, A5, and C, new dolabellane-type diterpene alkaloids, with lipid metabolism-promoting activities from the Egyptian medicinal food black cumin
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DOI：
10.1248/cpb.52.494
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发表时间：
2004-04-01
影响因子：
1.7
通讯作者：
Yoshikawa, M
中科院分区：
文献类型：
--
作者：
Morikawa, T;Xu, FM;Yoshikawa, M
从埃及药用食品黑孜然（黑种草的种子）的甲醇提取物中分离出新的dolabellane型二萜生物碱，黑素A（3），A（4），A（5）和C。它们的绝对构型是根据化学和物理化学证据确定的。发现黑色素可降低原代培养小鼠肝细胞中的甘油三酯水平，特别是黑色素A的活性与降血脂剂氯贝特相当。
New dolabellane-type diterpene alkaloids, nigellamines A(3), A(4), A(5), and C, were isolated from the methanolic extract of an Egyptian medicinal food, black cumin (the seeds of Nigella sativa). Their absolute configurations were determined on the basis of chemical and physicochemical evidence. Nigellamines were found to lower triglyceride levels in primary cultured mouse hepatocytes, and in particular, the activity of nigellamine A, was equivalent to that of the hypolipidemic agent, clofibrate.