Ion and nutrient uptake by malaria parasite-infected erythrocytes
Ion and nutrient uptake by malaria parasite-infected erythrocytes
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DOI：
10.1111/j.1462-5822.2012.01790.x
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发表时间：
2012-07-01
影响因子：
3.4
通讯作者：
Desai, Sanjay A.
中科院分区：
文献类型：
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作者：
Desai, Sanjay A.
感染疟原虫的红细胞对各种有机和无机溶质的渗透性增加。虽然这些渗透性的变化已经知道了几十年，运输的分子基础是未知的和激烈的争论。CLAG3是一种以前被认为在细胞粘附中起作用的寄生虫蛋白，最近被认为与疟原虫表面阴离子通道（PSAC）的形成有关，PSAC是一种介导大多数溶质摄取的不寻常的小电导离子通道。与运输研究一致，clag基因在所有疟原虫中是保守的，但在其他属中不存在。所编码的蛋白质与宿主膜是一体的，这也是电生理学所预测的。一个重要的问题是功能性通道是由CLAG3单独形成还是通过与其他蛋白质的相互作用形成。在任何一种情况下，基因鉴定都应该促进我们对寄生虫生物学的理解，并可能导致新的治疗方法。
Erythrocytes infected with malaria parasites have increased permeability to diverse organic and inorganic solutes. While these permeability changes have been known for decades, the molecular basis of transport was unknown and intensively debated. CLAG3, a parasite protein previously thought to function in cytoadherence, has recently been implicated in formation of the plasmodial surface anion channel (PSAC), an unusual small conductance ion channel that mediates uptake of most solutes. Consistent with transport studies, the clag genes are conserved in all plasmodia but are absent from other genera. The encoded protein is integral to the host membrane, as also predicted by electrophysiology. An important question is whether functional channels are formed by CLAG3 alone or through interactions with other proteins. In either case, gene identification should advance our understanding of parasite biology and may lead to new therapeutics.