Oral administration of sodium selenite minimizes cisplatin toxicity on proximal tubules of rats
Oral administration of sodium selenite minimizes cisplatin toxicity on proximal tubules of rats
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DOI：
10.1385/bter:83:3:251
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发表时间：
2001-12-01
影响因子：
3.9
通讯作者：
Bianchi, MLP
中科院分区：
文献类型：
--
作者：
Camargo, SMR;Francescato, HDC;Bianchi, MLP
顺铂（c-DDP）是一种广泛使用的抗肿瘤药物，其主要副作用是肾毒性。静脉内或腹膜内施用的硒已被证明可以针对 c-DDP 诱导的大鼠肾毒性提供保护。在本研究中，进一步研究了口服亚硒酸钠对c-DDP毒性的保护作用。单独使用 c-DDP 治疗的动物表现出尿量增加、肌酐清除率 (GFR) 降低以及尿 N-乙酰基-(β-n-氨基葡萄糖苷酶) (NAG) 同工酶 B 活性升高。当在 c-DDP 之前给予亚硒酸钠时，大鼠表现出 GFR 下降较少，尿量增加延迟，并且尿 NAG 同工酶 B 活性没有增加。建议在c-DDP给药前给予单剂量亚硒酸钠，虽然不能防止肾功能恶化，但可以部分保护大鼠免受早期近端肾小管损伤。
Cisplatin (c-DDP) is a widely used antineoplastic drug whose main side effect is nephrotoxicity. Selenium, administered intravenously or intraperitoneally, has been shown to provided protection against c-DDP-induced nephrotoxicity in rats. in the present study, the protective effect of orally administered sodium selenite on c-DDP toxicity was further examined. Animals treated with c-DDP alone showed increased urinary volume, decreased creatinine clearance (GFR), and a rise in urinary N-acetyl-(beta -n-glucosaminidase) (NAG) isoenzyme B activity. When sodium selenite as given prior to c-DDP, rats showed less GFR decline, delayed urinary volume increases, and no urinary NAG isoenzyme B activity increment. It is suggested that a single oral dose of sodium selenite given prior to c-DDP administration, although not preventing deterioration of renal function, partially protects rats from early proximal tubular injury.