Wave emission on interacting heterogeneities in cardiac tissue
Wave emission on interacting heterogeneities in cardiac tissue
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DOI：
10.1103/physreve.82.021926
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发表时间：
2010-08-31
影响因子：
2.4
通讯作者：
Yoshikawa, Kenichi
中科院分区：
文献类型：
--
作者：
Hoerning, Marcel;Takagi, Seiji;Yoshikawa, Kenichi
心律失常是跳动心脏中纤维性颤动样状态的前兆，与螺旋波有关，螺旋波很可能被钉扎到异质性上。远场起搏（FFP）是一种很有前途的方法，通过使用组织中的异质性作为内部起搏部位来终止这种波。在这项研究中，我们调查的作用，多种障碍和他们之间的相互作用，在FFP。我们发现，一个次要的附近的障碍物可以显着调制的最小电场FFP。此外，我们表明，在心脏组织培养中可以观察到基本上相同的效果，这是一个强大的实验模型来模拟心脏活动。这里，各向同性的细胞分布导致局部分布的去极化位点的域形成。次级障碍物和局部去极化位点的域形成都可以调制能量需求以在障碍物上产生波传播。我们的理论结果得到了心肌细胞单层实验的证实。这一结果可能是有用的，为未来的应用FFP到一个真实的跳动的心脏。
Cardiac arrhythmias, a precursor of fibrillationlike states in the beating heart, are associated with spiral waves, which are likely to become pinned to heterogeneities. Far-field pacing (FFP) is a promising method for terminating such waves by using heterogeneities in the tissue as internal pacing sites. In this study we investigated the role of multiple obstacles and their interaction during FFP. We show that a secondary nearby obstacle can significantly modulate the minimum electrical field in FFP. Further, we show that essentially the same effect can be observed in cardiac tissue culture, which is a powerful experimental model to simulate heart activity. Here, an isotropic cell distribution leads to domain formation of locally distributed depolarization sites. Both secondary obstacles and domain formation of local depolarization sites can modulate energy requirements to originate wave propagation on obstacles. Our theoretical result was confirmed by experiments with cardiomyocyte monolayers. This result may be useful for the future application of FFP to a real beating heart.