Tyramine injections reduce locust viability
Tyramine injections reduce locust viability
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DOI：
10.1007/bf03543233
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发表时间：
2000-06
影响因子：
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通讯作者：
H. Torfs;W. Van Poyer;J. Poels;E. Swinnen;A. De Loof;J. Broeck
中科院分区：
文献类型：
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作者：
H. Torfs;W. Van Poyer;J. Poels;E. Swinnen;A. De Loof;J. Broeck
在蝗虫的神经系统中，酪胺是章鱼胺合成的直接前体，作为章鱼胺类似物，酪胺可以激活章鱼胺受体。此外，在迁徙蝗虫和黑腹果蝇中特异性酪胺受体的鉴定表明它是一种重要的递质或调节剂候选者。本文报道了反复注射酪胺降低了标准血吸虫末龄幼虫的生存能力。此外，观察到反复酪胺治疗的亚致死效应是最后一次蜕皮的延迟。此外，成年雌性的产卵也被延缓和/或急剧减少。这些效应与某些“杀虫”章鱼胺受体激动剂（如甲脒和苯基咪唑烷）的亚致死效应相似。由于某些甲脒化合物也被证明是克隆酪胺受体的激动剂，因此不能排除酪胺给药的某些致死或亚致死后果是与特定酪胺受体相互作用的结果。
In the locust nervous system, tyramine is the direct precursor for octopamine synthesis and, as an octopamine analogue, it can activate octopamine receptors. Furthermore, the identification of specific tyramine receptors inLocusta migratoriaandDrosophila melanogastersuggests that it is an important transmitter or modulator candidate. In this paper, we report that repeated tyramine injections reduced the viability of last instar larvae ofLocustaandSchistocerca.In addition, a retardation of the last ecdysis was observed as a sublethal effect of the repeated tyramine treatment. Moreover, egg deposition by adult females was also retarded and/or drastically reduced. These effects show similarity to sublethal effects described for certain “insecticidal” octopamine receptor agonists, such as formamidines and phenylimi-noimidazolidines. Since certain formamidine compounds were also shown to be agonists for the cloned tyramine receptors, it cannot be excluded that some lethal or sublethal consequences of tyramine administration are the result of an interaction with specific tyramine receptors.