Early life experience primes resistance to oxidative stress
Early life experience primes resistance to oxidative stress
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DOI：
10.1242/jeb.072231
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发表时间：
2012-08-01
影响因子：
2.8
通讯作者：
Metcalfe, Neil B.
中科院分区：
文献类型：
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作者：
Costantini, David;Monaghan, Pat;Metcalfe, Neil B.
早期的压力暴露对达尔文学派健康的损害程度可能取决于其严重程度，轻微的压力暴露实际上具有刺激作用，并可能通过对压力刺激的兴奋反应而产生有益的影响。我们需要了解这样的兴奋过程，以确定早期环境如何帮助形成适应有机体在成年环境中最可能经历的条件的表型。我们利用斑马雀(Taeniopygia Guttata)检验了这一假设，即在成年后面临高热应激时，早年暴露于轻度热应激的人比没有预先暴露于热应激或早年暴露于高热应激的人遭受的氧化应激更少。我们的发现表明，生命早期暴露在温和的热应激下，使系统在成年后遇到热应激时，能够更好地抵御氧化应激。这些发现指出了一种潜在的机制，将早期生活经历与未来达尔文式的健康联系起来。
The extent to which early stress exposure is detrimental to Darwinian fitness may depend on its severity, with mild stress exposure actually having a stimulatory and, possibly, beneficial effect through a hormetic response to the stressful stimulus. We need to understand such hormetic processes to determine how the early environment can help shape a phenotype adapted to the conditions the organism is most likely to experience in its adult environment. Using the zebra finch (Taeniopygia guttata), we tested the hypothesis that individuals exposed to mild heat stress earlier in life will suffer less oxidative stress when faced with high heat stress in adulthood than will individuals either not pre-exposed to heat stress or exposed to high heat stress earlier in life. Our findings demonstrate that early life exposure to mild heat stress primes the system to better withstand oxidative stress when encountering heat stress as an adult. These findings point to a potential mechanism linking early life experiences to future Darwinian fitness.