Prognostic factors for the clinical severity of keratoconjunctivitis sicca in patients with Sjogren's syndrome
Prognostic factors for the clinical severity of keratoconjunctivitis sicca in patients with Sjogren's syndrome
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DOI：
10.1136/bjo.2011.202812
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发表时间：
2012-02-01
影响因子：
4.1
通讯作者：
Wee, Won Ryang
中科院分区：
文献类型：
--
作者：
Chung, Jin Kwon;Kim, Mee Kum;Wee, Won Ryang
目的探讨预后免疫学特征能否预测干燥综合征（SS）患者干燥性角膜结膜炎（KCS）的严重程度。方法121例确诊为SS患者，随访1年以上。根据牛津方案和对治疗的反应，将患者分为轻度KCS组（Mi-KCS, n = 65）或中度至重度KCS组（MS-KCS, n = 56）。这些组根据KCS的临床严重程度和相关风湿病的存在（原发性SS vs继发性SS）再细分为两组。比较各组抗ro / la抗体、类风湿因子、泪液白细胞介素(IL)-17水平及Schirmer试验结果。结果MS-KCS组总SS和原发SS的抗ro /SSA抗体和抗la /SSB抗体浓度显著高于Mi-KCS组，MS-KCS组总SS和原发SS的抗la /SSB抗体含量显著高于Mi-KCS组，MS-KCS组总SS和原发SS的平均泪液IL-17浓度均显著高于Mi-KCS组。结论血清抗la /SSB抗体、血清抗ro /SSA抗体和泪液IL-17可能与原发性SS患者KCS的临床严重程度密切相关。
Aims To determine whether prognostic immunological profiles predict the severity of keratoconjunctivitis sicca (KCS) in patients with Sjogren's syndrome (SS).Methods 121 patients diagnosed with SS and followed for at least 1 year were enrolled in this study. Patients were allocated to either a mild KCS group (Mi-KCS; n = 65) or to a moderate to severe KCS group (MS-KCS; n = 56) based on the Oxford scheme and response to treatment. These groups were each sub-divided into two groups based on the clinical severity of KCS and the presence of associated rheumatic disease (primary SS vs secondary SS). Anti-Ro/anti-La antibody, rheumatoid factor and tear interleukin (IL)-17 levels and Schirmer test results were compared between each group.Results Anti-Ro/SSA antibody and anti-La/SSB antibody concentrations were significantly higher in the MS-KCS group than in the Mi-KCS group for total and primary SS. The presence of anti-La/SSB antibody was significantly higher in the MS-KCS than the Mi-KCS group for total and primary SS. The mean tear IL-17 concentration in the MS-KCS group was significantly higher than in the Mi-KCS group for both total SS and primary SS patients.Conclusion Serum anti-La/SSB antibody, serum anti-Ro/SSA antibody and tear IL-17 are likely to be strongly involved in the clinical severity of KCS in patients with primary SS.