TRANSFERRIN METABOLISM IN ALCOHOLIC LIVER-DISEASE
TRANSFERRIN METABOLISM IN ALCOHOLIC LIVER-DISEASE
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DOI：
10.1002/hep.1840050503
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发表时间：
1985-01-01
期刊：
影响因子：
13.5
通讯作者：
SHERLOCK, S
中科院分区：
文献类型：
--
作者：
POTTER, BJ;CHAPMAN, RWG;SHERLOCK, S
使用纯化的 125I 标记的转铁蛋白在 11 名酗酒患者中研究了转铁蛋白的代谢；六名患有脂肪肝，五名患有肝硬化。六名每天饮酒量少于 40 克的健康受试者作为对照组进行研究。与对照组相比，酗酒组的平均分解代谢率和血浆容量没有显着差异。酒精性肝硬化患者的平均血清转铁蛋白浓度显着降低（1.8 .+-. 0.3 gm/L 对比 2.9 .+-. 0.2；p < 0.01），这是由于全身合成减少（0.9 .+-. 0.2 mg/kg/hr 对比 1.8 .+-. 0.2；p < 0.01）。相反，在酒精性脂肪肝患者中，与对照组相比，平均全身转铁蛋白合成（2.4±0.3mg/kg/hr）显着增加（p<0.05）。对于所有酗酒患者，血清转铁蛋白与转铁蛋白合成相关（r = +0.70；p < 0.01），但血清铁则不然。这些结果表明，在酒精性肝硬化中，转铁蛋白合成减少，可能反映出肝脏合成能力下降。相反，在酒精性脂肪肝患者中，转铁蛋白的周转速度加快。
The metabolism of transferrin was studied using purified 125I-labeled transferrin in 11 alcoholic patients; six with fatty liver and five with cirrhosis. Six healthy subjects whose alcohol intake was less than 40 gm daily were studied as a control group. There were no significant differences in the mean fractional catabolic rate and plasma volume in the alcoholic groups when compared with control subjects. A significantly decreased mean serum transferrin concentration was found in the alcoholic cirrhotic patients (1.8 .+-. 0.3 gm per liter vs. 2.9 .+-. 0.2; p < 0.01), resulting from diminished total body synthesis (0.9 .+-. 0.2 mg per kg per hr vs. 1.8 .+-. 0.2; p < 0.01). In contrast, in the patients with alcoholic fatty liver, the mean total body transferrin synthesis (2.4 .+-. 0.3 mg per kg per hr) was significantly increased when compared with controls (p < 0.05). For all the alcoholic patients, the serum transferrin correlated with transferrin synthesis (r = +0.70; p < 0.01) but the serum iron did not. These results suggest that, in alcoholic cirrhosis, transferrin synthesis is decreased, probably reflecting diminished synthetic capacity by the liver. In contrast, in patients with alcoholic fatty liver, transferrin turnover is accelerated.