Physical inactivity and smoking increase risk for serious infections in older women.
Physical inactivity and smoking increase risk for serious infections in older women.
复制标题
缺乏身体活动和吸烟会增加老年女性严重感染的风险。
DOI：
10.1111/j.1532-5415.2000.tb03867.x
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发表时间：
2000
影响因子：
6.3
通讯作者：
Guralnik,JM
中科院分区：
文献类型：
--
作者：
Leveille,SG;Gray,S;LaCroix,AZ;Ferrucci,L;Black,DJ;Guralnik,JM
目的：本研究调查了大型健康维护组织 (HMO) 参与者的绝经后女性需要住院治疗的感染的健康和行为危险因素。方法：参与者为 1365 名年龄 55 至 80 岁、总体健康的女性，随访时间长达 6 年。自动出院记录中首先列出的感染诊断用于识别感染是入院主要原因的住院治疗。这些严重感染的潜在危险因素是根据基线问卷信息和基线前和随访期间的自动 HMO 记录确定的。使用多变量逻辑回归方法检查与入院相关的感染风险。结果：73 名女性总共 90 次入院，其中感染是主要的出院诊断。感染的独立预测因素行为是缺乏身体活动（调整后优势比 = 4.08；95% CI，1.73–9.63）和吸烟（调整后优势比 = 2.64；95% CI，1.11–6.26）。癌症和肺部疾病的发生也与感染风险增加有关。这些关联与年龄、体重指数、功能状态和其他健康指标无关。结论：缺乏运动和吸烟等可改变的危险因素可能使老年女性面临严重感染的风险，尽管因果关系尚未得到解释。该领域的进一步研究可能会产生旨在减轻老年人口严重感染负担的新策略。
OBJECTIVE:This study examined health and behavioral risk factors for infections that required hospitalization in postmenopausal women who were enrollees of a large health maintenance organization (HMO).METHODS:Participants were 1365 generally healthy women aged 55 to 80 years who were followed for up to 6 years. Infection diagnoses listed first in the automated hospital discharge records were used to identify hospitalizations for which infections were the primary cause of admission. Potential risk factors for these serious infections were identified from baseline questionnaire information and automated HMO records from before baseline and during follow‐up. Risks for infections associated with hospital admission were examined using multivariate logistic regression methods.RESULTS:Seventy‐three women had a total of 90 hospital admissions in which infection was the primary discharge diagnosis. Behaviors that were independent predictors of infection were physical inactivity (adj. odds ratio = 4.08; 95% CI, 1.73–9.63) and smoking (adj. odds ratio = 2.64; 95% CI, 1.11–6.26). Incident cancer and lung disease were also associated with increased risk of infection. These associations were independent of age, body mass index, functional status, and other measures of health.CONCLUSIONS:Modifiable risk factors such as physical inactivity and smoking may place older women at risk for serious infections although the causal link is yet to be explained. Further research in this area may lead to new strategies aimed at reducing the serious burden of infections in the older population.