Integrated assessment of visual perception abnormalities in psychotic disorders and relationship with clinical characteristics
Integrated assessment of visual perception abnormalities in psychotic disorders and relationship with clinical characteristics
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DOI：
10.1017/s0033291718002477
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发表时间：
2019-07-01
影响因子：
6.9
通讯作者：
Ongur, Dost
中科院分区：
文献类型：
--
作者：
Turkozer, Halide Bilge;Hasoglu, Tuna;Ongur, Dost
背景资料。视觉系统被认为是精神分裂症病理和功能障碍的重要部位。在这项研究中，我们使用可能在临床上适用的任务组评估了精神障碍患者的不同视觉知觉功能，并评估了它们与患者症状严重程度的关系，以及与健康参与者的分裂类型特征的关系。使用包括视觉空间工作记忆(VSWM)、速度辨别(VD)、轮廓整合、视觉背景加工和后向掩蔽任务的成套测验，对28例精神分裂症和分裂情感障碍患者(n=28)和31例健康对照组(n=31)的视觉功能进行了评估。患者组在VD、轮廓积分和VSWM任务中表现出显著较低的表现。两组在视觉背景加工任务上的表现没有差异，在后向掩蔽任务中，不同水平的刺激间间隔也没有差异。在患者组中，在VSWM、VD和轮廓积分任务中的表现与阴性症状严重程度相关，但与其他症状维度无关。在健康对照组中，VSWM和VD的表现也与阴性的系统类型特征相关。综上所述，这些结果显示了精神病患者在多个视觉处理任务中的显著异常，增加了与这些条件下的视觉异常有关的文献。此外，我们的结果表明，在患者和健康人中，视觉加工障碍与消极症状维度有关。
Background. The visual system is recognized as an important site of pathology and dysfunction in schizophrenia. In this study, we evaluated different visual perceptual functions in patients with psychotic disorders using a potentially clinically applicable task battery and assessed their relationship with symptom severity in patients, and with schizotypal features in healthy participants.Methods. Five different areas of visual functioning were evaluated in patients with schizophrenia and schizoaffective disorder (n = 28) and healthy control subjects (n = 31) using a battery that included visuospatial working memory (VSWM), velocity discrimination (VD), contour integration, visual context processing, and backward masking tasks.Results. The patient group demonstrated significantly lower performance in VD, contour integration, and VSWM tasks. Performance did not differ between the two groups on the visual context processing task and did not differ across levels of interstimulus intervals in the backward masking task. Performances on VSWM, VD, and contour integration tasks were correlated with negative symptom severity but not with other symptom dimensions in the patient group. VSWM and VD performances were also correlated with negative sychizotypal features in healthy controls.Conclusion. Taken together, these results demonstrate significant abnormalities in multiple visual processing tasks in patients with psychotic disorders, adding to the literature implicating visual abnormalities in these conditions. Furthermore, our results show that visual processing impairments are associated with the negative symptom dimension in patients as well as healthy individuals.