The long-acting phosphodiesterase inhibitor tadalafil does not influence athletes' VO2max, aerobic, and anaerobic thresholds in normoxia
The long-acting phosphodiesterase inhibitor tadalafil does not influence athletes' VO2max, aerobic, and anaerobic thresholds in normoxia
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DOI：
10.1055/s-2007-965131
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发表时间：
2008-02-01
影响因子：
2.5
通讯作者：
Guidetti, L.
中科院分区：
文献类型：
--
作者：
Di Luigi, L.;Baldari, C.;Guidetti, L.
虽然实验研究表明，在健康训练的受试者中，磷酸二酯酶-5抑制剂(PDE-5I)西地那非可以提高低氧而不是常氧条件下的运动能力，但还没有关于PDE-5I半衰期较长的他达拉非影响的研究。为了评估他达拉非在常氧最大运动试验中是否影响机能参数和运动成绩，我们采用双盲交叉方案对14名健康男性运动员进行了研究。每名运动员在服用安慰剂或他达拉非(治疗剂量：20毫克)后，在自行车测功器上进行了两次测试。分别于运动前、呼吸阈值(IVT)、无氧阈值(IAT)、氧耗量(V)、氧分压(IVT)、无氧阈值(IAT)、氧脉搏(V)、氧分压(VT)、氧分压(IAT)、血乳酸、呼吸交换率、感觉耗氧率、动脉血压(BP)、心率(HR)、氧脉搏(V)等指标进行检测。与安慰剂相比，单次服用他达拉非可显著降低运动前后的收缩压(p<；0.05)，在IVT时降低(V)比DOT O-2/HR(13.3+/-1.8对14.5+/-2.1 mL.节拍(-1)；p=0.03)，但不改变DOT O-2max、IVT或IAT的个体(V)。在健康的运动员中，20毫克的他达拉非对体能相关参数、运动耐量和对常氧下最大运动的心肺反应没有实质性影响；高剂量/长时间使用是否会影响野外条件下的健康和/或运动表现仍有待验证。
Whereas experimental studies showed that in healthy trained subjects, the phosphodiesterase-5 inhibitor (PDE-5i) sildenafil improves exercise capacity in hypoxia and not in normoxia, no studies on the effects of the long half-life PDE-5i tadalafil exist. In order to evaluate whether tadalafil influences functional parameters and performance during a maximal exercise test in normoxia, we studied 14 healthy male athletes in a double-blind cross-over protocol. Each athlete performed two tests on a cycle ergometer, both after placebo or tadalafil (at therapeutic dose: 20 mg) administration. Oxygen consumption ((V) over dot O-2), blood lactate, respiratory exchange ratio, rate of perceived exertion, arterial blood pressure (BP), heart frequency (HR) and oxygen pulse ((V) over dot O-2/HR) were evaluated before exercise, at individual ventilatory and anaerobic thresholds (IVT and IAT), at (V) over dot O-2max and during recovery. Compared to placebo, a single tadalafil administration significantly reduced systolic BP before and after exercise (p < 0.05), decreased (V) over dot O-2/HR at IVT (13.3+/-1.8 vs. 14.5+/-2.1 mL.beat(-1); p = 0.03), but did not modify individual (V) over dot O-2max, IVT, or IAT. In healthy athletes, 20 mg of tadalafil does not substantially influence physical fitness-related parameters, exercise tolerance, and cardiopulmonary responses to maximal exercise in normoxia; it remains to be verified if higher doses/prolonged use influence health and/or sport performance in field conditions.