Protocells: Modular Mesoporous Silica Nanoparticle-Supported Lipid Bilayers for Drug Delivery.
Protocells: Modular Mesoporous Silica Nanoparticle-Supported Lipid Bilayers for Drug Delivery.
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DOI：
10.1002/smll.201502119
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发表时间：
2016-04-27
期刊：
影响因子：
--
通讯作者：
Brinker CJ
中科院分区：
文献类型：
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作者：
Butler KS;Durfee PN;Theron C;Ashley CE;Carnes EC;Brinker CJ
介孔二氧化硅纳米颗粒修饰的脂质双层，称为“原始细胞”，代表了一类潜在的治疗和治疗诊断递送载体。靶向给药领域提出了相当大的挑战，不能用一个单一的“灵丹妙药”来解决。因此，原始细胞被设计成由可互换的生物相容性组件组成的模块化平台。中孔二氧化硅核可以具有可变的尺寸和形状以引导生物分布，并且具有受控的孔径和表面化学以容纳不同的货物。包封的支持的脂质双层可以用靶向和运输配体以及PEG修饰，以实现选择性结合、货物的内体逃逸、药物流出防止和有效的治疗递送，同时保持体内胶体稳定性。这篇小型综述描述了该平台的各个组成部分，包括介孔二氧化硅纳米颗粒核心和支持的脂质双层，它们的组装（通过多种技术）成原始细胞，以及基于体外和体内研究（包括生物相容性和毒性评估）的原始细胞的组合（通常是协同作用）性能。最后，我们评论了许多新出现的变化的原始细胞的主题和未来的方向为原始细胞的研究。
Mesoporous silica nanoparticle supported-lipid bilayers, termed ‘protocells,’ represent a potentially transformative class of therapeutic and theranostic delivery vehicles. The field of targeted drug delivery poses considerable challenges that cannot be addressed with a single ‘magic bullet’. Consequently the protocell has been designed as a modular platform composed of interchangeable biocompatible components. The mesoporous silica core can have variable size and shape to direct biodistribution and controlled pore size and surface chemistry to accommodate diverse cargos. The encapsulating supported lipid bilayer can be modified with targeting and trafficking ligands as well as PEG to effect selective binding, endosomal escape of cargo, drug efflux prevention, and potent therapeutic delivery, while maintaining in vivo colloidal stability. This mini-review describes the individual components of the platform, including the mesoporous silica nanoparticle core and supported lipid bilayer, their assembly (by multiple techniques) into a protocell, and the combined, often synergistic, performance of the protocell based on in vitro and in vivo studies including assessment of biocompatibility and toxicity. We close by commenting on the many emerging variations of the protocell theme and the future directions for protocell research.