Dissociative anesthesia and striatal neuronal electrophysiology.
Dissociative anesthesia and striatal neuronal electrophysiology.
复制标题
分离麻醉和纹状体神经元电生理学。
DOI：
10.1002/syn.890090111
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Freeman,AS
中科院分区：
文献类型：
--
作者：
Kelland,MD;Chiodo,LA;Freeman,AS
与局部麻醉、瘫痪大鼠相比，游离麻醉剂氯胺酮不改变纹状体神经元自发活动的数目或纹状体神经元的基础放电频率，90%的细胞呈现I型纹状体神经元波形。水合氯醛麻醉可抑制自发性活动的I型细胞的出现和放电频率，但不改变II型纹状体神经元的活动。大脑皮层刺激优先激活瘫痪大鼠和水合氯醛麻醉大鼠的II型细胞。因此，在游离麻醉下，研究自发活跃的I型纹状体神经元是可能的。然而，研究II型纹状体神经元需要一种激活方法，如皮质刺激。
Compared with results obtained in locally anesthetized, paralyzed rats, the dissociative anesthetic ketamine did not alter either the number of spontaneously active striatal neurons or the basal firing rate of striatal neurons; 90% of these cells exhibited the type I striatal neuron waveform. Chloral hydrate anesthesia suppressed both the occurrence and the firing rate of spontaneously active type I cells, but did not alter the activity of type II striatal neurons. Cortical stimulation preferentially activated type II cells in paralyzed rats and in chloral hydrate‐anesthetized rats. Thus, under dissociative anesthesia it is possible to study spontaneously active type I striatal neurons. However, a method of activation such as cortical stimulation is necessary to study type II striatal neurons.