High-fat, high-sucrose, and high-cholesterol diets accelerate tumor growth and metastasis in tumor-bearing mice
High-fat, high-sucrose, and high-cholesterol diets accelerate tumor growth and metastasis in tumor-bearing mice
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DOI：
10.1080/01635580701499537
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发表时间：
2007-01-01
影响因子：
2.9
通讯作者：
Sumiyoshi, Maho
中科院分区：
文献类型：
--
作者：
Kimura, Yoshiyuki;Sumiyoshi, Maho
流行病学研究表明，各种癌症发生的危险因素与代谢症状密切相关，如肥胖、高脂血症和高热量饮食过量引起的胰岛素抵抗。然而，在荷瘤小鼠中，高热量饮食引起的肿瘤生长和转移的机制尚未阐明。在这项研究中，我们研究了高脂肪（1117），高糖（HS），高胆固醇（HC）或低脂/低糖（LF/LS）饮食对荷瘤小鼠肿瘤生长和转移的影响。血管生成因子，如血浆瘦素和单核细胞趋化蛋白-1（MCP-1）的增加后，植入肿瘤，而相反，抗血管生成因子，脂联素，减少后，植入肿瘤的小鼠喂食HF，HS，或HC饮食相比，LF/LS饮食。此外，我们发现，血管内皮生长因子，缺氧诱导因子-1 α和MCP-1的表达水平在小鼠的肿瘤喂食HF，HS，或HC的饮食相比，那些喂食LF/LS饮食的小鼠增加。这些结果提示，这3种饮食促进肿瘤生长和转移的机制可能与血管生成因子的增加和抗血管生成因子的减少有关。
Epidemiological studies indicate that the risk factors for the development of various cancers are closely associated with metabolic symptoms such as obesity, hyperlipidemia, and insulin resistance caused by the excess consumption of high-calorie diets. However, the mechanisms of tumor growth and metastasis caused by feeding a high-calorie diet have not been clarified yet in tumor-bearing mice. In this study, we examined the effects of a high-fat (1117), a high-sucrose (HS), a high-cholesterol (HC) or a low-fat/low-sucrose (LF/LS) diet on tumor growth and metastasis in tumor-bearing mice. Angiogenic factors such as plasma leptin and monocyte chemoattractant protein-1 (MCP-1) were increased after the implantation of tumors, whereas conversely, an antiangiogenic factor, adiponectin, was reduced after the implantation of tumors in mice fed the HF, the HS, or the HC diet compared to LF/LS diet. Furthermore, we found that vascular endothelial growth factor, hypoxia inducible factor- 1 alpha and MCP-1 expression levels in tumors of mice fed the HF, the HS, or the HC diet were increased compared to those of mice fed the LF/LS diet. These findings suggest that the acceleration of tumor growth and metastasis by feeding the 3 diets may be due to the increase of angiogenic factors and the reduction of antiangiogenic factors.