Asymmetric cobalt-catalyzed Diels-Alder reactions of a boron-functionalized 1,3-diene with alkynes and allylboration with aldehydes
Asymmetric cobalt-catalyzed Diels-Alder reactions of a boron-functionalized 1,3-diene with alkynes and allylboration with aldehydes
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DOI：
10.1021/ol061153f
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发表时间：
2006-07-20
期刊：
影响因子：
5.2
通讯作者：
Harms, Klaus
中科院分区：
文献类型：
--
作者：
Hilt, Gerhard;Hess, Wilfried;Harms, Klaus
钴(I)催化的1-硼功能化的1，3-二烯的Diels-Alder反应是将三个简单的起始原料连接起来得到多官能化产物的一锅反应的关键步骤。本产品在手性配体如(S，S)-诺弗斯存在的情况下，在具有非常高的区域和非对映选择性以及良好的对映选择性的情况下，在立体合成的仲醇官能团旁边加入了一个立体的四元中心。
A cobalt(I)-catalyzed Diels-Alder reaction of a 1-boron-functionalized 1,3-diene is the key step in a one-pot reaction interconnecting three simple starting materials to obtain a multifunctionalized product. This product incorporates a stereogenic quaternary center next to a stereogenic secondary alcohol functionality generated with a very high degree of regio- and diastereoselectivity and good enantioselectivity in the presence of a chiral ligand such as (S,S)-Norphos.