Analytical Evaluation of GeneXpert CT/NG, the First Genetic Point-of-Care Assay for Simultaneous Detection of Neisseria gonorrhoeae and Chlamydia trachomatis
Analytical Evaluation of GeneXpert CT/NG, the First Genetic Point-of-Care Assay for Simultaneous Detection of Neisseria gonorrhoeae and Chlamydia trachomatis
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DOI：
10.1128/jcm.00806-13
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发表时间：
2013-06-01
影响因子：
9.4
通讯作者：
Guy, Rebecca
中科院分区：
文献类型：
--
作者：
Tabrizi, Sepehr N.;Unemo, Magnus;Guy, Rebecca
GeneXpert CT/NG对372株特征菌株进行评价。两种药物的敏感性均为10个基因组拷贝/反应。4株粘膜奈瑟菌和2株黄下奈瑟菌对2个淋球菌靶点中的1个呈阳性；然而，检测结果均为阴性。该试验具有高度的分析敏感性和特异性。
GeneXpert CT/NG was evaluated with 372 characterized bacterial strains. Sensitivity of 10 genome copies/reaction was obtained for both agents. Four Neisseria mucosa and two Neisseria subflava isolates were positive for one of two gonococcal targets; however, the assay flagged all as negative. The assay was analytically highly sensitive and specific.