DJ-1 promotes cell proliferation and tumor metastasis in esophageal squamous cell carcinoma via the Wnt/β-catenin signaling pathway
DJ-1 promotes cell proliferation and tumor metastasis in esophageal squamous cell carcinoma via the Wnt/β-catenin signaling pathway
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DJ-1通过Wnt/β-catenin信号通路促进食管鳞癌细胞增殖和肿瘤转移
DOI：
10.3892/ijo.2020.5005
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发表时间：
2020-05-01
影响因子：
5.2
通讯作者：
Liu, Yanqing
中科院分区：
文献类型：
--
作者：
Jin, Feng;Wang, Haibo;Liu, Yanqing
DJ-1是一种癌基因，已被报道为食管鳞状细胞癌（ESCC）患者生存不良的独立预后指标。本研究旨在探讨DJ-1在食管鳞癌细胞增殖和侵袭中的作用及其机制。在84例食管鳞癌组织标本中，DJ-1的表达水平上调，并与EMT生物标志物呈正相关。过表达和敲低实验表明DJ-1参与了体外ECA-109细胞的增殖、迁移、侵袭和EMT以及腹膜播散小鼠模型中广泛的腹膜种植。此外，目前的数据表明DJ-1可以激活Wnt/β-连环蛋白信号通路，介导ESCC的EMT和转移。结论：DJ-1通过激活Wnt/beta-catenin信号通路促进食管鳞癌的增殖、侵袭、转移和EMT。本研究结果提示DJ-1可能成为预防和治疗ESCC相关转移的一个有前景的治疗靶点。
DJ-1, an oncogene, has been reported to be an independent prognostic indicator of poor survival in patients with esophageal squamous cell carcinoma (ESCC). The aim of the present study was to investigate the role of DJ-1 in tumor cell proliferation and invasion in ESCC and its underlying mechanisms. It was observed that the expression level of DJ-1 was upregulated and positively associated with EMT biomarkers in 84 human ESCC tissue specimens. Overexpression and knockdown experiments demonstrated that DJ-1 was involved in proliferation, migration, invasion and EMT in ECA-109 cells in vitro and extensive peritoneal seeding in a peritoneal dissemination mice model. Furthermore, the present data revealed that DJ-1 could activate the Wnt/beta-catenin signaling pathway, which mediates the EMT and metastasis in ESCC. In conclusions, DJ-1 promoted proliferation, invasion, metastasis and the EMT in ESCC via activation of the Wnt/beta-catenin signal pathway. The present results suggested DJ-1 could represent a promising therapeutic target for the prevention and treatment of ESCC-related metastasis.