Potential ionic mechanism for repolarization differences between canine right and left atrium
Potential ionic mechanism for repolarization differences between canine right and left atrium
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DOI：
10.1161/hh1101.091266
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发表时间：
2001-06-08
影响因子：
20.1
通讯作者：
Nattel, S
中科院分区：
文献类型：
--
作者：
Li, DS;Zhang, LM;Nattel, S
实验和临床证据表明，左房(LA)在房颤(AF)中起着关键作用。在动物模型中，左房的复极速度快于右房(RA)，导致更稳定的折返回路和更短的固有周期。LA-RA复极差异的离子机制尚不清楚，因此，我们用全细胞膜片钳技术研究了犬心房肌细胞的离子电流和动作电位(AP)。快速延迟整流电流密度(I-Kr)在+20 mV时，LA组为1.83+/-0.10pA/pF，而RA组为1.15+/-0.07pA/pF，P
Experimental and clinical evidence suggests a critical role for the left atrium (LA) in atrial fibrillation (AF), In animal models, repolarization is faster in the LA than in the right atrium (RA), leading to more stable reentry circuits with a shorter intrinsic period in the LA. The ionic mechanisms underlying LA-RA repolarization differences are unknown, Therefore, we evaluated ionic currents and action potentials (APs) with the whole-cell patch clamp in isolated canine atrial myocytes. The density of the rapid delayed rectifier current (I-Kr) was greater in the LA leg, 1.83 +/-0.10 pA/pF at +20 mV) than in the RA (1.15 +/-0.07 pA/pF, P