Possible host-adaptation of SARS-CoV-2 due to improved ACE2 receptor binding in mink.
Possible host-adaptation of SARS-CoV-2 due to improved ACE2 receptor binding in mink.
复制标题
DOI：
10.1093/ve/veaa094
复制
发表时间：
2021-01
期刊：
影响因子：
5.3
通讯作者：
Eggink D
中科院分区：
文献类型：
--
作者：
Welkers MRA;Han AX;Reusken CBEM;Eggink D
在一些国家，水貂养殖场的严重急性呼吸系统综合征冠状病毒2型（SARS-CoV-2）感染越来越多，导致受影响养殖场的动物被大规模扑杀。最近的研究表明，在这些农场的人与水貂之间发生了多种人畜共患传染病。来自荷兰和丹麦的水貂来源的SARS-CoV-2序列在S蛋白受体结合结构域（RBD）中含有多个取代。分子模拟表明，这些取代增加了平均结合能，表明潜在的适应的SARS-CoV-2 S蛋白水貂血管紧张素转换酶2（ACE 2）受体。这些取代也可能影响人类ACE 2结合亲和力以及针对人类SARS-CoV-2 S蛋白RBD区域的体液免疫应答。我们希望强调这些观察结果，以提高认识，并敦促继续监测水貂（和其他动物）相关感染。
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections on mink farms are increasingly observed in several countries, leading to the massive culling of animals on affected farms. Recent studies showed multiple (anthropo)zoonotic transmission events between humans and mink on these farms. Mink-derived SARS-CoV-2 sequences from The Netherlands and Denmark contain multiple substitutions in the S protein receptor binding domain (RBD). Molecular modeling showed that these substitutions increase the mean binding energy, suggestive of potential adaptation of the SARS-CoV-2 S protein to the mink angiotensin-converting enzyme 2 (ACE2) receptor. These substitutions could possibly also impact human ACE2 binding affinity as well as humoral immune responses directed to the RBD region of the SARS-CoV-2 S protein in humans. We wish to highlight these observations to raise awareness and urge for the continued surveillance of mink (and other animal)-related infections.