Ovarian ecdysteroid biosynthesis and female germline stem cells
Ovarian ecdysteroid biosynthesis and female germline stem cells
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DOI：
10.1080/19336934.2017.1291472
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发表时间：
2017-01-01
期刊：
影响因子：
1.2
通讯作者：
Niwa, Ryusuke
中科院分区：
文献类型：
--
作者：
Ameku, Tomotsune;Yoshinari, Yuto;Niwa, Ryusuke
生殖系干细胞（GSCs）在整个成年期的配子发生中起着关键作用。干细胞的身份是由来自称为小生境的专门微环境的局部信号维持的。然而，目前尚不清楚系统信号如何调节干细胞活性以响应环境线索。在我们以前的文章中，我们报道了交配刺激雌性果蝇GSC增殖。交配诱导的GSC增殖是由卵巢蜕皮激素介导的，其生物合成受性肽信号正调控。在这里，我们的特点后羽化和交配后的表达模式的基因编码的蜕皮类固醇激素生成酶的卵巢。我们进一步研究了卵巢蜕皮激素的生物合成功能，在GSC的维持在交配的女性。我们还简要地讨论了蜕皮类固醇生成酶编码基因的调控和随后的蜕皮类固醇生物合成在成年果蝇卵巢。
The germline stem cells (GSCs) are critical for gametogenesis throughout the adult life. Stem cell identity is maintained by local signals from a specialized microenvironment called the niche. However, it is unclear how systemic signals regulate stem cell activity in response to environmental cues. In our previous article, we reported that mating stimulates GSC proliferation in female Drosophila. The mating-induced GSC proliferation is mediated by ovarian ecdysteroids, whose biosynthesis is positively controlled by Sex peptide signaling. Here, we characterized the post-eclosion and post-mating expression pattern of the genes encoding the ecdysteroidogenic enzymes in the ovary. We further investigated the biosynthetic functions of the ovarian ecdysteroid in GSC maintenance in the mated females. We also briefly discuss the regulation of the ecdysteroidogenic enzyme-encoding genes and the subsequent ecdysteroid biosynthesis in the ovary of the adult Drosophila.