Factors associated to lifestyle and risk of adult onset asthma
Factors associated to lifestyle and risk of adult onset asthma
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DOI：
10.1053/rmed.2003.1419
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发表时间：
2003-03-01
影响因子：
4.3
通讯作者：
Koskenvuo, M
中科院分区：
文献类型：
--
作者：
Huovinen, E;Kaprio, J;Koskenvuo, M
背景：哮喘患病率一直在增加，尤其是在发达国家。这种变化似乎与生活方式的变化有关。我们进行了一项前瞻性研究，以评估生活方式因素，包括吸烟，教育水平，体力活动和肥胖，对成人哮喘发作的影响。方法：对10597对最初无哮喘的成年双胞胎进行了9年的随访。主要的观察指标是医生诊断哮喘的问卷报告.采用逻辑回归分析来估计生活方式因素预测的哮喘风险，并对特应性和呼吸道症状进行校正。结果如下：基线肥胖增加哮喘风险（多变量校正OR= 3.00，95% 0：BMI大于或等于30的患者与正常体重BMI的患者相比：1.64-5.50：20-24.99）。较高的身高与较低的哮喘发病率相关。休闲时间体力活动对男性哮喘风险有轻微的保护作用（趋势P =0.037），而吸烟和教育对成人哮喘发作的风险没有显著影响。结论：肥胖与成人哮喘发病风险相关，而身高矮小和闲暇时间体力活动少可被认为是其他潜在的危险因素。(C)2002爱思唯尔科技有限公司。保留所有权利。
Background: Asthma prevalence has been increasing especially in developed countries. The change seems to be associated with changes in lifestyle. We have made a prospective study to assess the effect of lifestyle factors, including smoking, educational level, physical activity and obesity, on adult onset asthma. Methods: A population of 10597 adult twins, initially free of asthma was followed for 9 years. The main outcome measure was questionnaire- based report of physician diagnosed asthma. Logistic regression was used to estimate the risk of asthma predicted by lifestyle factors, with adjustment for atopy and respiratory symptoms. Results: Obesity at baseline increased asthma risk (multivariable adjusted OR=3.00,95% 0: 1.64-5.50 for those with BMI greater than or equal to30 compared to those with normal weight BMI: 20-24.99). Taller height was associated to lower asthma incidence. Leisure time physical activity had a slightly protective effect on asthma risk among men (P for trend=0.037), while smoking and education did not have signifcant effects on the risk of adult onset asthma. Conclusions: Obesity was associated to the risk of adult onset asthma, while short height and low leisure time physical activity can be considered as other potential risk factors. (C) 2002 Elsevier Science Ltd. All rights reserved.